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- Medical English LInking keywords finder for the PubMed Zipped Archive (ELIZA) -
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554339 occurrences (No.20 in the rank) during 5 years in the PubMed. [no cache] 500 found
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[frequency of next (right) word to clinical]
554339 occurrences (No.20 in the rank) during 5 years in the PubMed. [no cache] 500 found
| 132) All antibiotics in clinical use are facing eventual obsolesce as a result of the evolution and dissemination of resistance mechanisms, yet there are few new drug leads forthcoming from the pharmaceutical sector. |
| PMID:23654249 DOI:10.1021/sb300092n |
| 2015 ACS synthetic biology |
| * Opportunities for synthetic biology in antibiotics: expanding glycopeptide chemical diversity. |
| - Synthetic biology offers a new path for the exploitation and improvement of natural products to address the growing crisis in antibiotic resistance. All antibiotics in clinical use are facing eventual obsolesce as a result of the evolution and dissemination of resistance mechanisms, yet there are few new drug leads forthcoming from the pharmaceutical sector. Natural products of microbial origin have proven over the past 70 years to be the wellspring of antimicrobial drugs. Harnessing synthetic biology thinking and strategies can provide new molecules and expand chemical diversity of known antibiotic scaffolds to provide much needed new drug leads. The glycopeptide antibiotics offer paradigmatic scaffolds suitable for such an approach. We review these strategies here using the glycopeptides as an example and demonstrate how synthetic biology can expand antibiotic chemical diversity to help address the growing resistance crisis. |
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--- WordNet output for clinical ---