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ELIZA cgi-bash version rev. 1.90
- Medical English LInking keywords finder for the PubMed Zipped Archive (ELIZA) -
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kwic search for clinical out of >500 occurrences
554339 occurrences (No.20 in the rank) during 5 years in the PubMed. [cache]
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[frequency of next (right) word to clinical]
554339 occurrences (No.20 in the rank) during 5 years in the PubMed. [cache]
| 259) Based on two sets of molecular data and a simulation study, we show that violations of the regularity assumptions may lead to over-optimistic estimates of prediction accuracy and may therefore result in biased conclusions regarding the clinical utility of new biomarkers. |
| PMID:24036698 DOI:10.1093/bib/bbt059 |
| 2015 Briefings in bioinformatics |
| * On the validity of time-dependent AUC estimators. |
| - Recent developments in molecular biology have led to the massive discovery of new marker candidates for the prediction of patient survival. To evaluate the predictive value of these markers, statistical tools for measuring the performance of survival models are needed. We consider estimators of discrimination measures, which are a popular approach to evaluate survival predictions in biomarker studies. Estimators of discrimination measures are usually based on regularity assumptions such as the proportional hazards assumption. Based on two sets of molecular data and a simulation study, we show that violations of the regularity assumptions may lead to over-optimistic estimates of prediction accuracy and may therefore result in biased conclusions regarding the clinical utility of new biomarkers. In particular, we demonstrate that biased medical decision making is possible even if statistical checks indicate that all regularity assumptions are satisfied. |
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--- WordNet output for clinical ---