ELIZA

return kwic search for clinical out of >500 occurrences
554339 occurrences (No.20 in the rank) during 5 years in the PubMed. [no cache] 500 found

58) Here, we report the detailed clinical and laboratory workup of one of the most severe BCL11B-dependent atopic cases to date.

--- ABSTRACT ---

PMID:34887873 DOI:10.3389/fimmu.2021.788278

2021 Frontiers in immunology

* A Novel Germline Heterozygous BCL11B Variant Causing Severe Atopic Disease and Immune Dysregulation.

- B-cell lymphoma/leukemia 11B (BCL11B) is a C₂H₂ zinc finger transcription factor that is critically important for regulating the development and function of a variety of systems including the central nervous system, the skin, and the immune system. Germline heterozygous variants are associated with a spectrum of clinical disorders, including severe combined immunodeficiency as well as neurological, craniofacial, and dermal defects. Of these individuals, ~50% present with severe allergic disease. Here, we report the detailed clinical and laboratory workup of one of the most severe BCL11B-dependent atopic cases to date. Leveraging a zebrafish model, we were able to confirm a strong T-cell defect in the patient. Based on these data, we classify germline BCL11B-dependent atopic disease as a novel primary atopic disorder.

--- ABSTRACT END ---

[
right
kwic]

[frequency of next (right) word to clinical]

(1)48 trials	(20)4 phenotypes	(39)3 severity,	(58)2 examination
(2)29 and	(21)4 setting	(40)3 social	(59)2 experience
(3)28 studies	(22)4 treatment	(41)3 trials,	(60)2 genetics
(4)24 practice	(23)3 Trial	(42)3 use	(61)2 guidelines
(5)18 trial	(24)3 Trials	(43)3 variables,	(62)2 manifestations
(6)15 outcomes	(25)3 application	(44)2 PGx	(63)2 manifestations,
(7)9 data	(26)3 applications,	(45)2 Trials,	(64)2 needs
(8)7 settings	(27)3 characteristics,	(46)2 applicability	(65)2 oncology
(9)7 signs	(28)3 conditions	(47)2 assessments	(66)2 parameters
(10)7 utility	(29)3 data,	(48)2 benefits	(67)2 research
(11)5 impact	(30)3 decision	(49)2 case	(68)2 services
(12)5 relevance	(31)3 effectiveness	(50)2 checklist	(69)2 settings,
(13)5 studies,	(32)3 evidence	(51)2 conversations	(70)2 specimens
(14)4 care	(33)3 factors	(52)2 correlates	(71)2 survey
(15)4 diagnosis	(34)3 features	(53)2 courses	(72)2 syndrome
(16)4 efficacy	(35)3 health	(54)2 decision-making	(73)2 trial,
(17)4 levels	(36)3 isolates	(55)2 dental	(74)2 validity
(18)4 or	(37)3 outcomes,	(56)2 disease
(19)4 outcome	(38)3 populations	(57)2 epidemiology

add keyword

--- WordNet output for clinical --- =>客観的な態度の, 臨床の, 臨床治療の, 臨床, 分析的な, 冷静な, 客観的な, 病院に関するものだ, 病院関係の Overview of adj clinical The adj clinical has 2 senses (first 2 from tagged texts) 1. (14) clinical -- (relating to a clinic or conducted in or as if in a clinic and depending on direct observation of patients; "clinical observation"; "clinical case study") 2. (1) clinical -- (scientifically detached; unemotional; "he spoke in the clipped clinical monotones typical of police testimony") --- WordNet end ---