20) The time to reach a therapeutic aPTT was 2 hours shorter in the PDI compared to the PA group, 8 ± 4 hours versus 10 ± 4 hours, P = .015. |
PMID:23965335 DOI:10.1177/1076029613501542 |
2015 Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis |
* Evaluation of 2 nomogram-based strategies for dosing argatroban in patients with known or suspected heparin-induced thrombocytopenia. |
- No study has compared 2 different dosing strategies for argatroban titration nor has any published nomogram demonstrated improvement in outcomes. This study was conducted to evaluate the effectiveness of 2 argatroban nomograms on reaching therapeutic anticoagulation. Patients treated with argatroban were separated into 2 sliding scale groups, percentage adjustments (PAs) and predefined dose increments (PDIs). The primary outcome was the time to reach a therapeutic activated partial thromboplastin time (aPTT). The average initial dose and dose to achieve a therapeutic aPTT were similar between the groups. There was also no difference in the number of dose changes. The time to reach a therapeutic aPTT was 2 hours shorter in the PDI compared to the PA group, 8 ± 4 hours versus 10 ± 4 hours, P = .015. This study demonstrates a significant time advantage associated with a PDI nomogram compared to a PA nomogram but no difference with respect to the number of rate changes. |
(1)105 the | (10)6 conventional | (19)3 group | (28)2 groups |
(2)23 those | (11)5 controls, | (20)3 pure | (29)2 its |
(3)19 control | (12)5 placebo | (21)2 TCDD | (30)2 long |
(4)14 a | (13)5 untreated | (22)2 age-matched | (31)2 non-Hispanic |
(5)12 that | (14)4 Exo(Normoxic) | (23)2 baseline | (32)2 non-transgenic |
(6)10 controls | (15)4 all | (24)2 bur-prepared | (33)2 people |
(7)10 other | (16)4 patients | (25)2 children | (34)2 plain |
(8)9 healthy | (17)3 an | (26)2 controls), | (35)2 previous |
(9)9 their | (18)3 drug | (27)2 experimental | (36)2 vehicle |
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