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270181 occurrences (No.97 in the rank) during 5 years in the PubMed. [no cache] 500 found

29) Over the course of 6 months, spermatogenesis underwent significant incremental impairment on the inoculated side as compared to the contralateral side (P < 0.001).

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PMID:24528296 DOI:10.1111/and.12239

2015 Andrologia

* Experimental Escherichia coli epididymitis in rats: assessment of testicular involvement in a long-term follow-up.

- The objective of this study was to investigate spermatogenesis and testicular inflammation in a rat model of unilateral Escherichia coli epididymitis in a long-term follow-up. Unilateral epididymitis was induced in 30 Sprague-Dawley rats by injecting E. coli into the right ductus deferens. Oral antimicrobial treatment with sparfloxacin (50 mg kg(-1) body weight/7 days) was administered in half of the animals 24 h after infection. Five treated and five untreated rats were killed at 2 weeks, 3 months and 6 months after infection. Spermatogenesis was investigated using a histological semi-quantitative score. The presence of inflammatory cells (B- and T lymphocytes, macrophages and granulocytes) in the testicular tissues was evaluated by immunohistochemistry. The testes were sterile at all times. Over the course of 6 months, spermatogenesis underwent significant incremental impairment on the inoculated side as compared to the contralateral side (P < 0.001). However, overall spermatogenesis scores were not significantly different between treated and untreated animals (P > 0.3 at each time point). Finally, loss of testicular architecture on the inoculated side was not associated with any cellular inflammatory response. Thus, adjuvant therapies need to be studied, and research is necessary on how to prevent deterioration of testicular function in bacterial epididymitis.

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(1)105 the	(10)6 conventional	(19)3 group	(28)2 groups
(2)23 those	(11)5 controls,	(20)3 pure	(29)2 its
(3)19 control	(12)5 placebo	(21)2 TCDD	(30)2 long
(4)14 a	(13)5 untreated	(22)2 age-matched	(31)2 non-Hispanic
(5)12 that	(14)4 Exo(Normoxic)	(23)2 baseline	(32)2 non-transgenic
(6)10 controls	(15)4 all	(24)2 bur-prepared	(33)2 people
(7)10 other	(16)4 patients	(25)2 children	(34)2 plain
(8)9 healthy	(17)3 an	(26)2 controls),	(35)2 previous
(9)9 their	(18)3 drug	(27)2 experimental	(36)2 vehicle

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--- WordNet output for compared --- =>前年同期比で(は) Overview of verb compare The verb compare has 4 senses (first 3 from tagged texts) 1. (57) compare -- (examine and note the similarities or differences of; "John compared his haircut to his friend's"; "We compared notes after we had both seen the movie") 2. (12) compare -- (be comparable; "This car does not compare with our line of Mercedes") 3. (9) compare, liken, equate -- (consider or describe as similar, equal, or analogous; "We can compare the Han dynasty to the Romans"; "You cannot equate success in financial matters with greed") 4. compare -- (to form the comparative or superlative form on an adjective or adverb) --- WordNet end ---