ELIZA cgi-bash version rev. 1.90
- Medical English LInking keywords finder for the PubMed Zipped Archive (ELIZA) -

return kwic search for compared to out of >500 occurrences
270181 occurrences (No.97 in the rank) during 5 years in the PubMed. [no cache] 500 found
6) In tongue tissues, both 4NQO + GSE and 4NQO + Res treatment correlated with a decreased proliferation (BrdU labeling index) but increased apoptotic death (TUNEL-positive cells) as compared to the 4NQO group.
--- ABSTRACT ---
PMID:24243690 DOI:10.1002/mc.22099
2015 Molecular carcinogenesis
* Grape seed extract and resveratrol prevent 4-nitroquinoline 1-oxide induced oral tumorigenesis in mice by modulating AMPK activation and associated biological responses.
- Preventive measures against oral carcinogenesis are urgently warranted to lower the high morbidity and mortality associated with this malignancy worldwide. Here, we investigated the chemopreventive efficacy of grape seed extract (GSE) and resveratrol (Res) in 4-nitroquinoline-1-oxide (4NQO)-induced tongue tumorigenesis in C57BL/6 mice. Following 8 weeks of 4NQO exposure (100 µg/ml in drinking water), mice were fed with either control AIN-76A diet or diet containing 0.2% GSE (w/w) or 0.25% Res (w/w) for 8 subsequent weeks, while continued on 4NQO. Upon termination of the study at 16 weeks, tongue tissues were histologically evaluated for hyperplasia, dysplasia, and papillary lesions, and then analyzed for molecular targets by immunohistochemistry. GSE and Res feeding for 8 weeks, moderately decreased the incidence, but significantly prevented the multiplicity and severity of 4NQO-induced preneoplastic and neoplastic lesions, without any apparent toxicity. In tongue tissues, both 4NQO + GSE and 4NQO + Res treatment correlated with a decreased proliferation (BrdU labeling index) but increased apoptotic death (TUNEL-positive cells) as compared to the 4NQO group. Furthermore, tongue tissues from both the 4NQO + GSE and 4NQO + Res groups showed an increase in activated metabolic regulator phospho-AMPK (Thr172) and decreased autophagy flux marker p62. Together, these findings suggest that GSE and Res could effectively prevent 4NQO-induced oral tumorigenesis through modulating AMPK activation, and thereby, inhibiting proliferation and inducing apoptosis and autophagy, as mechanisms of their efficacy.
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[frequency of next (right) word to compared to]
(1)105 the (10)6 conventional (19)3 group (28)2 groups
(2)23 those (11)5 controls, (20)3 pure (29)2 its
(3)19 control (12)5 placebo (21)2 TCDD (30)2 long
(4)14 a (13)5 untreated (22)2 age-matched (31)2 non-Hispanic
(5)12 that (14)4 Exo(Normoxic) (23)2 baseline (32)2 non-transgenic
(6)10 controls (15)4 all (24)2 bur-prepared (33)2 people
(7)10 other (16)4 patients (25)2 children (34)2 plain
(8)9 healthy (17)3 an (26)2 controls), (35)2 previous
(9)9 their (18)3 drug (27)2 experimental (36)2 vehicle

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--- WordNet output for compared --- =>前年同期比で(は) Overview of verb compare The verb compare has 4 senses (first 3 from tagged texts) 1. (57) compare -- (examine and note the similarities or differences of; "John compared his haircut to his friend's"; "We compared notes after we had both seen the movie") 2. (12) compare -- (be comparable; "This car does not compare with our line of Mercedes") 3. (9) compare, liken, equate -- (consider or describe as similar, equal, or analogous; "We can compare the Han dynasty to the Romans"; "You cannot equate success in financial matters with greed") 4. compare -- (to form the comparative or superlative form on an adjective or adverb) --- WordNet end ---