ELIZA

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183) Many patients with sarcoidosis are chronically dependent on steroids and there is limited data on the use of steroid-sparing agents.

--- ABSTRACT ---

PMID:24075023 DOI:10.5414/CN108025

2015 Clinical nephrology

* Mycophenolate mofetil as a steroid-sparing agent in sarcoid-associated renal disease.

- Steroids are the mainstay of treatment for renal sarcoidosis. Many patients with sarcoidosis are chronically dependent on steroids and there is limited data on the use of steroid-sparing agents. This is a case of a patient that has remained in remission using mycophenolate mofetil (MMF) as a steroid-sparing agent. The patient is a 56-year-old female with a history of sarcoidosis diagnosed by lymph node biopsy who developed 3 episodes of acute kidney injury (AKI) in the setting of exacerbations of her sarcoidosis, each responding to prednisone treatment. Due to possible lifelong need for prednisone, MMF was started as a steroid-sparing treatment. She tolerated the MMF well and has now been steroidfree for 22 months. There have been only a few case reports about the use of MMF as a steroid-sparing agent in sarcoid-associated renal disease, in which patients could be successfully weaned off steroids. This is the longest reported follow-up of a patient being off steroids while on MMF. It is also notable for the patient having a relapse on the MMF which responded to an increased dose. MMF should be studied further as a potential steroid-sparing agent in the treatment of sarcoid associated renal disease.

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(1)70 from	(14)7 revealed	(27)3 analyses	(40)2 at
(2)55 were	(15)7 support	(28)3 can	(41)2 by
(3)32 null	(16)7 was	(29)3 concerning	(42)2 clearly
(4)26 on	(17)6 analysis	(30)3 in	(43)2 clustering
(5)19 and	(18)6 obtained	(31)3 indicated	(44)2 have
(6)18 for	(19)5 collection	(32)3 may	(45)2 here
(7)17 suggest	(20)5 sets	(33)3 the	(46)2 highlight
(8)13 are	(21)5 showed	(34)3 which	(47)2 mining
(9)11 set	(22)5 we	(35)3 with	(48)2 show
(10)11 to	(23)4 demonstrate	(36)3 would	(49)2 shows
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(12)7 collected	(25)4 provide	(38)2 also
(13)7 indicate	(26)4 regarding	(39)2 as

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--- WordNet output for data --- =>データ, 資料 Overview of noun data The noun data has 1 sense (first 1 from tagged texts) 1. (76) data, information -- (a collection of facts from which conclusions may be drawn; "statistical data") Overview of noun datum The noun datum has 1 sense (first 1 from tagged texts) 1. (5) datum, data point -- (an item of factual information derived from measurement or research) --- WordNet end ---