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286534 occurrences (No.87 in the rank) during 5 years in the PubMed. [cache]

428) The scalability of the oxidative cyclization was demonstrated, and the product cyclophosphoramidates were shown to be valuable synthons, including for tether removal.

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PMID:34665630 DOI:10.1021/acs.joc.1c01483

2021 The Journal of organic chemistry

* Highly Regio- and Diastereoselective Tethered Aza-Wacker Cyclizations of Alkenyl Phosphoramidates.

- We present highly diastereoselective tethered aza-Wacker cyclization reactions of alkenyl phosphoramidates. "Arming" the phosphoramidate tether with 5-chloro-8-quinolinol was essential to achieving >20:1 diastereoselectivity in these reactions. The substrate scope with respect to alkenyl alcohols and phosphoramidate tether was extensively explored. The scalability of the oxidative cyclization was demonstrated, and the product cyclophosphoramidates were shown to be valuable synthons, including for tether removal. With chiral alkenyl precursors, enantiopure cyclic phosphoramidates were formed.

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(1)169 that	(11)5 good	(21)3 that,	(31)2 leadership
(2)48 a	(12)5 using	(22)2 altered	(32)2 on
(3)34 the	(13)5 with	(23)2 benefits	(33)2 positive
(4)18 in	(14)4 comparable	(24)2 decreases	(34)2 potential
(5)17 to	(15)4 for	(25)2 elevated	(35)2 robustness
(6)16 by	(16)4 how	(26)2 evidence	(36)2 significantly
(7)9 an	(17)4 its	(27)2 greater	(37)2 similar
(8)8 significant	(18)3 improved	(28)2 higher	(38)2 statistically
(9)7 null	(19)3 no	(29)2 highly	(39)2 successful
(10)7 efficacy	(20)3 several	(30)2 increased	(40)2 survival

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--- WordNet output for demonstrated --- Overview of verb demonstrate The verb demonstrate has 4 senses (first 4 from tagged texts) 1. (24) show, demo, exhibit, present, demonstrate -- (give an exhibition of to an interested audience; "She shows her dogs frequently"; "We will demo the new software in Washington") 2. (22) prove, demonstrate, establish, show, shew -- (establish the validity of something, as by an example, explanation or experiment; "The experiment demonstrated the instability of the compound"; "The mathematician showed the validity of the conjecture") 3. (2) attest, certify, manifest, demonstrate, evidence -- (provide evidence for; stand as proof of; show by one's behavior, attitude, or external attributes; "His high fever attested to his illness"; "The buildings in Rome manifest a high level of architectural sophistication"; "This decision demonstrates his sense of fairness") 4. (1) demonstrate, march -- (march in protest; take part in a demonstration; "Thousands demonstrated against globalization during the meeting of the most powerful economic nations in Seattle") Overview of adj demonstrated The adj demonstrated has 1 sense (first 1 from tagged texts) 1. (1) demonstrated -- (having been demonstrated or verified beyond doubt) --- WordNet end ---