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23) Collectively, the reported data support the conclusion that PDS-HNTs nanocomposite fibrous structures hold potential in the development of a bioactive scaffold for regenerative endodontics.
2015 Journal of tissue engineering and regenerative medicine
* A novel three-dimensional scaffold for regenerative endodontics: materials and biological characterizations.
- An electrospun nanocomposite fibrous material holds promise as a scaffold, as well as a drug-delivery device to aid in root maturogenesis and the regeneration of the pulp-dentine complex. A novel three-dimensional (3D) nanocomposite scaffold composed of polydioxanone (PDS II®) and halloysite nanotubes (HNTs) was designed and fabricated by electrospinning. Morphology, structure, mechanical properties and cell compatibility studies were carried out to evaluate the effects of HNTs incorporation (0.5-10 wt% relative to PDS w/w). Overall, a 3D porous network was seen in the different fabricated electrospun scaffolds, regardless of the HNT content. The incorporation of HNTs at 10 wt% led to a significant (p < 0.0001) fibre diameter increase and a reduction in scaffold strength. Moreover, PDS-HNTs scaffolds supported the attachment and proliferation of human-derived pulp fibroblast cells. Quantitative proliferation assay performed with human dental pulp-derived cells as a function of nanotubes concentration indicated that the HNTs exhibit a high level of biocompatibility, rendering them good candidates for the potential encapsulation of distinct bioactive molecules. Collectively, the reported data support the conclusion that PDS-HNTs nanocomposite fibrous structures hold potential in the development of a bioactive scaffold for regenerative endodontics.
=>発達, 開発, 産物, 進展
Overview of noun development
The noun development has 9 senses (first 7 from tagged texts)
1. (52) development -- (act of improving by expanding or enlarging or refining; "he congratulated
them on their development of a plan to meet the emergency"; "they funded research and development")
2. (46) development, evolution -- (a process in which something passes by degrees to a different
stage (especially a more advanced or mature stage); "the development of his ideas took many years";
"the evolution of Greek civilization"; "the slow development of her skill as a writer")
3. (11) growth, growing, maturation, development, ontogeny, ontogenesis -- ((biology) the process of
an individual organism growing organically; a purely biological unfolding of events involved in an
organism changing gradually from a simple to a more complex level; "he proposed an indicator of
osseous development in children")
4. (9) development -- (a recent event that has some relevance for the present situation; "recent
developments in Iraq"; "what a revolting development!")
5. (7) exploitation, development -- (the act of making some area of land or water more profitable or
productive or useful; "the development of Alaskan resources"; "the exploitation of copper deposits")
6. (6) development -- (a district that has been developed to serve some purpose; "such land is
practical for small park developments")
7. (4) development -- (a state in which things are improving; the result of developing (as in the
early part of a game of chess); "after he saw the latest development he changed his mind and became
a supporter"; "in chess your should take care of your development before moving your queen")
8. development, developing -- (processing a photosensitive material in order to make an image
visible; "the development and printing of his pictures took only two hours")
9. development -- ((music) the section of a composition or movement (especially in sonata form)
where the major musical themes are developed and elaborated)
--- WordNet end ---