* Prenatal and perinatal anesthesia and the long-term cognitive sequelae: a review.
- Many children have cognitive weaknesses or impairments of uncertain etiology. A variety of gestational and early-life variables contribute to normative neurocognitive development with countless events potentially hindering successful neural development. Recent research suggests that anesthesia has the potential to negatively affect fetal brain development both prenatally and perinatally. Some of the anesthesiology research suggests that under certain circumstances, children may have a heightened risk for attention-deficit hyperactivity disorder, learning disorders, and perhaps other issues. Though there are no prospective studies evaluating neurocognitive function in children after neonatal exposure to anesthetics, there are several retrospective reviews that demonstrate temporary neurological sequelae after prolonged anesthetic exposure in young children and larger studies identifying long-term neurodevelopmental impairment after neonatal surgery and anesthesia. Studies also suggest a heightened vulnerability likely during the first trimester, particularly when neurons are undergoing rapid development. Specifically, heightened vulnerability to cerebral dysfunction tends to be associated with exposure to multiple anesthetic agents, longer duration of exposure, and multiple episodes of exposure to anesthetic agents.
=>発達, 開発, 産物, 進展
Overview of noun development
The noun development has 9 senses (first 7 from tagged texts)
1. (52) development -- (act of improving by expanding or enlarging or refining; "he congratulated
them on their development of a plan to meet the emergency"; "they funded research and development")
2. (46) development, evolution -- (a process in which something passes by degrees to a different
stage (especially a more advanced or mature stage); "the development of his ideas took many years";
"the evolution of Greek civilization"; "the slow development of her skill as a writer")
3. (11) growth, growing, maturation, development, ontogeny, ontogenesis -- ((biology) the process of
an individual organism growing organically; a purely biological unfolding of events involved in an
organism changing gradually from a simple to a more complex level; "he proposed an indicator of
osseous development in children")
4. (9) development -- (a recent event that has some relevance for the present situation; "recent
developments in Iraq"; "what a revolting development!")
5. (7) exploitation, development -- (the act of making some area of land or water more profitable or
productive or useful; "the development of Alaskan resources"; "the exploitation of copper deposits")
6. (6) development -- (a district that has been developed to serve some purpose; "such land is
practical for small park developments")
7. (4) development -- (a state in which things are improving; the result of developing (as in the
early part of a game of chess); "after he saw the latest development he changed his mind and became
a supporter"; "in chess your should take care of your development before moving your queen")
8. development, developing -- (processing a photosensitive material in order to make an image
visible; "the development and printing of his pictures took only two hours")
9. development -- ((music) the section of a composition or movement (especially in sonata form)
where the major musical themes are developed and elaborated)
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