* Porous collagen-hydroxyapatite scaffolds with mesenchymal stem cells for bone regeneration.
- Current bone grafting materials have significant limitations for repairing maxillofacial and dentoalveolar bone deficiencies. An ideal bone tissue-engineering construct is still lacking. The purpose of the present study was first to synthesize and develop a collagen-hydroxyapatite (Col-HA) composite through controlled in situ mineralization on type I collagen fibrils with nanometer-sized apatite crystals, and then evaluate their biologic properties by culturing with mouse and human mesenchymal stem cells (MSCs). We synthesized Col-HA scaffolds with different Col:HA ratios. Mouse C3H10T1/2 MSCs and human periodontal ligament stem cells (hPDSCs) were cultured with scaffolds for cell proliferation and biocompatibility assays. We found that the porous Col-HA composites have good biocompatibility and biomimetic properties. The Col-HA composites with ratios 80:20 and 50:50 composites supported the attachments and proliferations of mouse MSCs and hPDSCs. These findings indicate that Col-HA composite complexes have strong potentials for bone tissue regeneration.
=>いろいろな, 違った, 異なった, 様々の, 種々の, 異なる, 変わった
Overview of adj different
The adj different has 5 senses (first 4 from tagged texts)
1. (88) different -- (unlike in nature or quality or form or degree; "took different approaches to
the problem"; "came to a different conclusion"; "different parts of the country"; "on different
sides of the issue"; "this meeting was different from the earlier one")
2. (41) different -- (distinctly separate from the first; "that's another (or different) issue
altogether")
3. (2) different -- (differing from all others; not ordinary; "advertising that strives continually
to be different"; "this new music is certainly different but I don't really like it")
4. (1) unlike, dissimilar, different -- (marked by dissimilarity; "for twins they are very unlike";
"people are profoundly different")
5. different -- (distinct or separate; "each interviewed different members of the community")
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