242) Several animal models for Huntington's disease (HD) have been created in order to investigate mechanisms of disease, and to evaluate the potency of novel therapies. |
PMID:24013873 DOI:10.1007/7854_2013_245 |
2015 Current topics in behavioral neurosciences |
* Transgenic Rat Models of Huntington's Disease. |
- Several animal models for Huntington's disease (HD) have been created in order to investigate mechanisms of disease, and to evaluate the potency of novel therapies. Here, we describe the characteristics of the two transgenic rat models: transgenic rat model of HD (fragment model) and the Bacterial Artificial Chromosome HD model (full-length model). We discuss their genetic, behavioural, neuropathological and neurophysiological features. |
(1)100 *null* | (17)4 (PD) | (33)3 to | (49)2 condition, |
(2)39 and | (18)4 activity | (34)2 (CHD) | (50)2 development |
(3)16 is | (19)4 outcome | (35)2 (COPD) | (51)2 interval |
(4)13 in | (20)4 severity, | (36)2 (CVD), | (52)2 many |
(5)12 of | (21)4 the | (37)2 (GERD) | (53)2 multi-sectoral |
(6)9 (FMD) | (22)4 who | (38)2 (LSD) | (54)2 on |
(7)8 risk | (23)3 (CAD) | (39)2 (SC) | (55)2 onset |
(8)7 severity | (24)3 compared | (40)2 Control | (56)2 onset, |
(9)6 progression | (25)3 control | (41)2 activity, | (57)2 outbreaks |
(10)6 that | (26)3 course | (42)2 are | (58)2 patterns |
(11)6 was | (27)3 free | (43)2 as | (59)2 phobia |
(12)5 (CVD) | (28)3 has | (44)2 associated | (60)2 prevention |
(13)5 or | (29)3 management | (45)2 burden | (61)2 processes |
(14)5 state | (30)3 may | (46)2 by | (62)2 progression, |
(15)4 (AD) | (31)3 patients | (47)2 can | (63)2 surveillance |
(16)4 (HD) | (32)3 states | (48)2 characterized | (64)2 usually |
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