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422715 occurrences (No.39 in the rank) during 5 years in the PubMed. [no cache] 500 found
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422715 occurrences (No.39 in the rank) during 5 years in the PubMed. [no cache] 500 found
| 347) The study aimed to evaluate the possible contribution of CTLA-4 exon 1 49 A>G polymorphism to the pathogenesis of ITP and its relation to age of disease onset, clinical course, and response to therapy. |
| PMID:24023266 DOI:10.1177/1076029613502254 |
| 2015 Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis |
| * Lack of impact of cytotoxic T-lymphocyte antigen 4 gene exon 1 polymorphism on susceptibility to or clinical course of egyptian childhood immune thrombocytopenic purpura. |
| - Dysfunctional T-lymphocyte immunity plays an important role in the pathophysiology of immune thrombocytopenic purpura (ITP). Cytotoxic T-lymphocyte antigen 4 (CTLA-4)-a surface marker expressed on T regulatory cells and activated T lymphocytes-is a negative modulator of T-cell responses. Polymorphisms of the CTLA-4 may alter the level of antigen expression and hence may influence immune regulation. The study aimed to evaluate the possible contribution of CTLA-4 exon 1 49 AThe study aimed to evaluate the possible contribution of CTLA-4 exon 1 49 A>G polymorphism to the pathogenesis of ITP and its relation to age of disease onset, clinical course, and response to therapy.gt;G polymorphism to the pathogenesis of ITP and its relation to age of disease onset, clinical course, and response to therapy. Genotyping of CTLA-4 exon 1 49 A>G was performed in 100 pediatric patients with ITP and 259 healthy individuals by polymerase chain reaction-restricted fragment length polymorphism. No significant differences existed in genotype or allele distributions between patients and controls for the studied polymorphism. Comparable genotypes and allele frequencies were obtained between the 2 groups after their stratification by age of disease onset, clinical course, or response to therapy. In conclusion, CTLA-4 exon 1 49 A>G polymorphism is not associated with susceptibility to ITP in the Egyptian population; neither it affects the clinical picture of the disease. |
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| (1)100 *null* | (17)4  (PD) |
(33)3 to |
(49)2 condition, |
| (2)39 and |
(18)4 activity |
(34)2 (CHD) |
(50)2 development |
| (3)16 is |
(19)4 outcome |
(35)2 (COPD) |
(51)2 interval |
| (4)13 in |
(20)4 severity, |
(36)2 (CVD), |
(52)2 many |
| (5)12 of |
(21)4 the |
(37)2 (GERD) |
(53)2 multi-sectoral |
| (6)9 (FMD) |
(22)4 who |
(38)2 (LSD) |
(54)2 on |
| (7)8 risk |
(23)3 (CAD) |
(39)2 (SC) |
(55)2 onset |
| (8)7 severity |
(24)3 compared |
(40)2 Control |
(56)2 onset, |
| (9)6 progression |
(25)3 control |
(41)2 activity, |
(57)2 outbreaks |
| (10)6 that |
(26)3 course |
(42)2 are |
(58)2 patterns |
| (11)6 was |
(27)3 free |
(43)2 as |
(59)2 phobia |
| (12)5 (CVD) |
(28)3 has |
(44)2 associated |
(60)2 prevention |
| (13)5 or |
(29)3 management |
(45)2 burden |
(61)2 processes |
| (14)5 state |
(30)3 may |
(46)2 by |
(62)2 progression, |
| (15)4 (AD) |
(31)3 patients |
(47)2 can |
(63)2 surveillance |
| (16)4 (HD) |
(32)3 states |
(48)2 characterized |
(64)2 usually |
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