kwic
due+to
due+to
right
off
ON
119
1
100
500
strict
ELIZA cgi-bash version rev. 1.90
- Medical English LInking keywords finder for the PubMed Zipped Archive (ELIZA) -
return
kwic search for due to out of >500 occurrences
319715 occurrences (No.67 in the rank) during 5 years in the PubMed. [no cache] 500 found
--- ABSTRACT ---
--- ABSTRACT END ---
[frequency of next (right) word to due to]
319715 occurrences (No.67 in the rank) during 5 years in the PubMed. [no cache] 500 found
| 119) Crocin, a constituent of saffron, has hepatoprotective effects due to its antioxidant activity. |
| PMID:23406950 DOI:10.1177/0748233713475519 |
| 2015 Toxicology and industrial health |
| * Evaluation of diazinon-induced hepatotoxicity and protective effects of crocin. |
| - Diazinon (DZN) is one of the most widely used insecticides in agricultural pest control. Previous studies have shown that DZN may induce hepatotoxicity. Reactive oxygen species and apoptosis pathways are involved in the toxicity of DZN. Crocin, a constituent of saffron, has hepatoprotective effects due to its antioxidant activity. In this study, we examined the effects of subacute DZN exposure and ameliorating effect of crocin on lipid peroxidation and pathological changes in rat liver. Moreover, protein levels of activated and total caspases-3 and -9 and Bax/Bcl-2 ratio were measured. Five groups of rats were used in the experiment. Corn oil (control), DZN (15 mg/kg per day, orally) and crocin (12.5, 25 and 50 mg/kg per day, intraperitoneally in combination with DZN) were given to male Wistar rats (n = 6) for 4 weeks. The level of malondialdehyde (MDA) increased significantly in DZN group compared with the control group (p < 0.05). MDA level decreased significantly in the group that received DZN plus 25 mg crocin (p < 0.001). No gross or histological evidence of treatment-related damage to the liver after oral exposure to DZN was observed. DZN also induced apoptosis through activation of caspases-9 and -3 and increasing Bax/Bcl-2 ratio. Crocin attenuated the activation of caspases and reduced the Bax/Bcl-2 ratio. It is concluded that subacute exposure to DZN induces oxidative stress-mediated apoptosis and crocin may reduce DZN-induced hepatotoxicity. |
[
right
kwic]
(1)115  the |
(10)4 insufficient |
(19)2 cardiac |
(28)2 pannus |
| (2)30 its |
(11)3 changes |
(20)2 common |
(29)2 potential |
| (3)30 their |
(12)3 increased |
(21)2 condom |
(30)2 previous |
| (4)20 a |
(13)3 low |
(22)2 environmental |
(31)2 primary |
| (5)9 an |
(14)3 multiple |
(23)2 extreme |
(32)2 progressive |
| (6)5 limited |
(15)3 poor |
(24)2 inadequate |
(33)2 prolonged |
| (7)4 differences |
(16)3 possible |
(25)2 inflammation |
(34)2 similarities |
| (8)4 different |
(17)2 abnormal |
(26)2 lack |
(35)2 some |
| (9)4 high |
(18)2 anthropogenic |
(27)2 major |
add keyword
--- WordNet output for due ---