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319715 occurrences (No.67 in the rank) during 5 years in the PubMed. [no cache] 500 found

125) Artemether-lumefantrine combination is widely in use due to its effectiveness against Plasmodium falciparum.

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PMID:24115283 DOI:10.1002/tox.21907

2015 Environmental toxicology

* Toxicity associated with repeated administration of artemether-lumefantrine in rats.

- Chemotherapy remains an important approach in the fight against malaria. Artemether-lumefantrine combination is widely in use due to its effectiveness against Plasmodium falciparum. Misuse in the form of multiple repeated doses of this anti-malaria drug is rampant in Nigeria. This study was designed to assess the hepatotoxic and clastogenic potential of extreme misuse of artemether-lumefantrine in rats. Graded doses of artemether-lumefantrine (1-5 mg/kg body weight) were administered by oral gavage for 6 weeks, twice daily, for 3 consecutive days per week. Artemether-lumefantrine, at all doses, did not have significant effects on the body and relative liver weight of treated group compared to the negative control group. The mean γ-glutamyltransferase, alanine, and aspartate aminotransaminase activity in groups of artemether-lumefantrine treated rats were significantly higher (p < 0.05) than that of the negative control group indicating that repeated administration of artemether-lumefantrine may be hepatotoxic. Findings from histological analyses of liver cross-section support the enzyme pattern of hepatoxicity. In addition, the drug, at all experimental doses, significantly induced (p < 0.05) formation of micronucleated polychromatic erythrocytes in the bone marrow cells of the treated rats compared with the negative control indicating clastogenic potential of the drug when misused.

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(1)115 the	(10)4 insufficient	(19)2 cardiac	(28)2 pannus
(2)30 its	(11)3 changes	(20)2 common	(29)2 potential
(3)30 their	(12)3 increased	(21)2 condom	(30)2 previous
(4)20 a	(13)3 low	(22)2 environmental	(31)2 primary
(5)9 an	(14)3 multiple	(23)2 extreme	(32)2 progressive
(6)5 limited	(15)3 poor	(24)2 inadequate	(33)2 prolonged
(7)4 differences	(16)3 possible	(25)2 inflammation	(34)2 similarities
(8)4 different	(17)2 abnormal	(26)2 lack	(35)2 some
(9)4 high	(18)2 anthropogenic	(27)2 major

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--- WordNet output for due --- =>1.予定の, 支払期日がきて, 当然支払われるべき, 2.支払[提出]期日, 満期日, 会費 Overview of noun due The noun due has 2 senses (first 1 from tagged texts) 1. (4) due -- (that which is deserved or owed; "give the devil his due") 2. due -- (a payment that is due (e.g., as the price of membership); "the society dropped him for non-payment of dues") Overview of adj due The adj due has 4 senses (first 2 from tagged texts) 1. (6) due -- (owed and payable immediately or on demand; "payment is due") 2. (1) due -- (scheduled to arrive; "the train is due in 15 minutes") 3. due -- (suitable to or expected in the circumstances; "all due respect"; "due cause to honor them"; "a long due promotion"; "in due course"; "due esteem"; "exercising due care") 4. ascribable, due, imputable, referable -- (capable of being assigned or credited to; "punctuation errors ascribable to careless proofreading"; "the cancellation of the concert was due to the rain"; "the oversight was not imputable to him") Overview of adv due The adv due has 1 sense (no senses from tagged texts) 1. due -- (directly or exactly; straight; "went due North") --- WordNet end ---