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- Medical English LInking keywords finder for the PubMed Zipped Archive (ELIZA) -
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319715 occurrences (No.67 in the rank) during 5 years in the PubMed. [no cache] 500 found
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319715 occurrences (No.67 in the rank) during 5 years in the PubMed. [no cache] 500 found
| 130) The use of pectin for colon-specific drug delivery has been extensively investigated; however, when used alone, pectin is often compromised due to its high solubility. |
| PMID:24471938 DOI:10.3109/10717544.2013.879965 |
| 2015 Drug delivery |
| * An in situ crosslinked compression coat comprised of pectin and calcium chloride for colon-specific delivery of indomethacin. |
| - The use of pectin for colon-specific drug delivery has been extensively investigated; however, when used alone, pectin is often compromised due to its high solubility. This study explored the feasibility of using an in situ compression-coated crosslinking system, composed of pectin and calcium chloride, for colon-specific drug delivery. A pectin/calcium chloride (P/Ca) coating was compressed onto a core tablet. The colon specificity of the compression-coated tablet was verified by dissolution, pharmacokinetics and scintigraphy with (99m)Tc labeling. The in situ pectin and calcium chloride gel slowed the release of indomethacin. The lag time varied between 3 h and 7 h depending on the amount of calcium chloride and the coating weight. Pectinase triggered the release of indomethacin from the compression-coated tablet, which was then accelerated by the calcium chloride in the coating layer. The compression-coated tablet had a prolonged tmax and apparent t1/2, as well as a decreased Cmax and AUC0-t, compared with the core tablet counterpart. Evaluation with γ-scintigraphy verified colon-specific delivery of the compression-coated tablet. In conclusion, the P/Ca in situ crosslinking system worked well for colon-specific drug delivery. |
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