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319715 occurrences (No.67 in the rank) during 5 years in the PubMed. [no cache] 500 found
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319715 occurrences (No.67 in the rank) during 5 years in the PubMed. [no cache] 500 found
| 236) He has been followed up by our pediatric cardiology department due to multiple cardiac anomalies. |
| PMID:24409942 DOI:10.3109/08820538.2013.839814 |
| 2015 Seminars in ophthalmology |
| * Congenital keratoglobus with multiple cardiac anomalies: a case presentation and literature review. |
| - Keratoglobus is a rare condition of bilateral corneal ectasia, which results in high myopia, irregular astigmatism, scarring, and rarely spontaneous globe rupture. Globoid protrusion of a clear, diffusely thin cornea is the pathology. The congenital form has been associated with blue sclera in which there is a systemic connective tissue disorder with abnormal collagen synthesis like Ehlers-Danlos syndrome, Marfan syndrome, and osteogenesis imperfecta. Some concomitant abnormalities reported with kertoglobus include joint hypermobility, dental and skeletal abnormalities, osteal fragility, and deafness. Acquired forms have been reported to be associated with vernal keratoconjunctivitis and thyroid ophthalmopathy. We report the case of a 16-year-old boy with keratoglobus who presented with a history of photophobia and a low vision in both eyes since birth. He has been followed up by our pediatric cardiology department due to multiple cardiac anomalies. He had hypermobility of large joints, easy bruising, thin and hyperextensible skin with visible veins, which were also described in his elder brother. We aimed to discuss the etiology and the association of keratoglobus with some systemic abnormalities caused by collogen tissue disturbance, and make a brief review about the recent literature concerning the management of keratoglobus patients. |
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