ELIZA

return kwic search for expression of out of >500 occurrences
286252 occurrences (No.88 in the rank) during 5 years in the PubMed. [cache]

32) We also discovered a concurrent over-expression of the mGLUR4 receptor in the eyes of these mice.

--- ABSTRACT ---

PMID:33074445 DOI:10.1007/s11010-020-03934-0

2021 Molecular and cellular biochemistry

* Regulation of the parental gene GRM4 by circGrm4 RNA transcript and glutamate-mediated neurovascular toxicity in eyes.

- Epigenetic memory plays crucial roles in gene regulation. It not only modulates the expression of specific genes but also has ripple effects on transcription as well as translation of other genes. Very often an alteration in expression occurs either via methylation or demethylation. In this context, "1-carbon metabolism" assumes a special significance since its dysregulation by higher levels of homocysteine; Hcy (known as hyperhomocysteinemia; HHcy), a byproduct of "1-Carbon Metabolism" during methionine biosynthesis leads to serious implications in cardiovascular, renal, cerebrovascular systems, and a host of other conditions. Currently, the circular RNAs (circRNAs) generated via non-canonical back-splicing events from the pre-mRNA molecules are at the center stage for their essential roles in diseases via their epigenetic manifestations. We recently identified a circular RNA transcript (circGRM4) that is significantly upregulated in the eye of cystathionine β-synthase-deficient mice. We also discovered a concurrent over-expression of the mGLUR4 receptor in the eyes of these mice. In brief, circGRM4 is selectively transcribed from its parental mGLUR4 receptor gene (GRM4) functions as a "molecular-sponge" for the miRNAs and results into excessive turnover of the mGLUR4 receptor in the eye in response to extremely high circulating glutamate concentration. We opine that this epigenetic manifestation potentially predisposes HHcy people to retinovascular malfunctioning.

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(1)32 the	(13)4 mutant	(24)2 KIF20B	(36)2 heat
(2)18 genes	(14)4 specific	(25)2 Ki-67	(37)2 miR-296
(4)8 a	(15)3 many	(26)2 MMP-1	(38)2 miR-627
(5)7 these	(16)3 mitochondrial	(27)2 NCS1	(39)2 miRNAs
(6)6 nuclear	(17)3 multiple	(29)2 SLCO2B1	(40)2 oncoproteins,
(7)5 Staphylococcus	(18)3 several	(30)2 VEGF	(41)2 platelet-derived
(8)5 pro-inflammatory	(19)3 vascular	(31)2 asSuGR,	(42)2 recombinant
(9)4 CYP3A4	(20)2 ACE-2	(32)2 cytokines/chemokines	(43)2 tight
(10)4 both	(21)2 ASIC1a,	(33)2 farnesoid
(11)4 inflammatory	(22)2 ATG5	(34)2 fibroblast
(12)4 its	(23)2 CCN1	(35)2 fibrogenic

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--- WordNet output for expression --- =>表現すること, 式, 表現, 表示, 言い回し, 表現法, 表情 Overview of noun expression The noun expression has 9 senses (first 6 from tagged texts) 1. (23) expression, look, aspect, facial expression, face -- (the feelings expressed on a person's face; "a sad expression"; "a look of triumph"; "an angry face") 2. (18) expression, manifestation, reflection, reflexion -- (expression without words; "tears are an expression of grief"; "the pulse is a reflection of the heart's condition") 3. (15) expression, verbal expression, verbalism -- (the communication (in speech or writing) of your beliefs or opinions; "expressions of good will"; "he helped me find verbal expression for my ideas"; "the idea was immediate but the verbalism took hours") 4. (5) saying, expression, locution -- (a word or phrase that particular people use in particular situations; "pardon the expression") 5. (4) formulation, expression -- (the style of expressing yourself; "he suggested a better formulation"; "his manner of expression showed how much he cared") 6. (4) formula, expression -- (a group of symbols that make a mathematical statement) 7. expression -- ((genetics) the process of expressing a gene) 8. construction, grammatical construction, expression -- (a group of words that form a constituent of a sentence and are considered as a single unit; "I concluded from his awkward constructions that he was a foreigner") 9. expression -- (the act of forcing something out by squeezing or pressing; "the expression of milk from her breast") --- WordNet end ---