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ELIZA cgi-bash version rev. 1.91
- Medical English LInking keywords finder for the PubMed Zipped Archive (ELIZA) -
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kwic search for expression of out of >500 occurrences
286252 occurrences (No.88 in the rank) during 5 years in the PubMed. [cache]
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286252 occurrences (No.88 in the rank) during 5 years in the PubMed. [cache]
| 4) Their exclusive expression of the C-type lectin receptor Langerin makes them prominent candidates for immunotherapy. |
| PMID:32522485 DOI:10.1016/j.jid.2020.05.098 |
| 2021 The Journal of investigative dermatology |
| * Notch-Mediated Generation of Monocyte-Derived Langerhans Cells: Phenotype and Function. |
| - Langerhans cells (LCs) in the skin are a first line of defense against pathogens but also play an essential role in skin homeostasis. Their exclusive expression of the C-type lectin receptor Langerin makes them prominent candidates for immunotherapy. For vaccine testing, an easily accessible cell platform would be desirable as an alternative to the time-consuming purification of LCs from human skin. Here, we present such a model and demonstrate that monocytes in the presence of GM-CSF, TGF-β1, and the Notch ligand DLL4 differentiate within 3 days into CD1a+Langerin+cells containing Birbeck granules. RNA sequencing of these monocyte-derived LCs (moLCs) confirmed gene expression of LC-related molecules, pattern recognition receptors, and enhanced expression of genes involved in the antigen-presenting machinery. On the protein level, moLCs showed low expression of costimulatory molecules but prominent expression of C-type lectin receptors. MoLCs can be matured, secrete IL-12p70 and TNF-α, and stimulate proliferation and cytokine production in allogeneic CD4+ and CD8+ T cells. In regard to vaccine testing, a recently characterized glycomimetic Langerin ligand conjugated to liposomes demonstrated specific and fast internalization into moLCs. Hence, these short-term in vitro‒generated moLCs represent an interesting tool to screen LC-based vaccines in the future. |
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(24)2 KIF20B |
(36)2 heat |
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(14)4 specific |
(25)2 Ki-67 |
(37)2 miR-296 |
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(15)3 many |
(26)2 MMP-1 |
(38)2 miR-627 |
| (5)7 these |
(16)3 mitochondrial |
(27)2 NCS1 |
(39)2 miRNAs |
| (6)6 nuclear |
(17)3 multiple |
(29)2 SLCO2B1 |
(40)2 oncoproteins, |
| (7)5 Staphylococcus |
(18)3 several |
(30)2 VEGF |
(41)2 platelet-derived |
| (8)5 pro-inflammatory |
(19)3 vascular |
(31)2 asSuGR, |
(42)2 recombinant |
| (9)4 CYP3A4 |
(20)2 ACE-2 |
(32)2 cytokines/chemokines |
(43)2 tight |
| (10)4 both |
(21)2 ASIC1a, |
(33)2 farnesoid |
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| (11)4 inflammatory |
(22)2 ATG5 |
(34)2 fibroblast |
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| (12)4 its |
(23)2 CCN1 |
(35)2 fibrogenic |
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--- WordNet output for expression ---