ELIZA

return kwic search for factors out of >500 occurrences
295043 occurrences (No.82 in the rank) during 5 years in the PubMed. [cache]

236) This scoping review aimed to map patients' and relatives' experiences of genetic testing and counseling for familial ALS and FTD and the factors influencing their decision to proceed with testing or counseling.

--- ABSTRACT ---

PMID:34054018 DOI:10.1097/WAD.0000000000000458

2021 Alzheimer disease and associated disorders

* Patient and Relative Experiences and Decision-making About Genetic Testing and Counseling for Familial ALS and FTD: A Systematic Scoping Review.

- Genetic testing and counseling is an emerging part of care for patients with amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) and their families. This scoping review aimed to map patients' and relatives' experiences of genetic testing and counseling for familial ALS and FTD and the factors influencing their decision to proceed with testing or counseling. Informed by the Joanna Briggs Institute methodology, 5 databases were systematically searched. Thirty studies from 39 references were included. A descriptive numerical summary analysis and narrative synthesis was conducted. Mostly positive diagnostic testing experiences were reported, but issues arose due to progressive disease and discordant results. Predictive testing impacted at-risk relatives, regardless of the result received, and psychosocial sequelae ranged from relief to guilt, worry or contemplating suicide. Four reproductive testing experiences were reported. Personal, familial and practical factors, and the lived experience of disease, informed decision-making. Greater uncertainty and complexity may be faced in familial ALS/FTD than in other late-onset neurodegenerative diseases due to clinical and genetic heterogeneity, and testing limitations. Genetic counseling models of care should consider this difference to ensure that individuals with, or at risk of, ALS/FTD are effectively managed. Implications for research and practice are discussed.

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(1)60 and	(12)8 related	(23)3 influence	(34)2 from
(2)55 null	(13)8 to	(24)3 is	(35)2 have
(3)41 that	(14)7 of	(25)3 relating	(36)2 impact
(4)31 for	(15)6 (e.g.,	(26)3 which	(37)2 involved
(5)29 associated	(16)6 contributing	(27)3 with	(38)2 shaping
(6)24 influencing	(17)5 on	(28)2 (including	(39)2 should
(7)20 were	(18)4 can	(29)2 (pre-COVID-19);	(40)2 using
(8)17 such	(19)4 like	(30)2 affecting	(41)2 varied
(9)15 in	(20)4 the	(31)2 and/or	(42)2 was
(10)11 are	(21)3 as	(32)2 at
(11)9 including	(22)3 included	(33)2 by

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--- WordNet output for factors --- Overview of noun factor The noun factor has 7 senses (first 4 from tagged texts) 1. (31) factor -- (anything that contributes causally to a result; "a number of factors determined the outcome") 2. (8) component, constituent, element, factor, ingredient -- (an abstract part of something; "jealousy was a component of his character"; "two constituents of a musical composition are melody and harmony"; "the grammatical elements of a sentence"; "a key factor in her success"; "humor: an effective ingredient of a speech") 3. (4) divisor, factor -- (one of two or more integers that can be exactly divided into another integer; "what are the 4 factors of 6?") 4. (1) agent, factor, broker -- (a businessman who buys or sells for another in exchange for a commission) 5. factor -- (any of the numbers (or symbols) that form a product when multiplied together) 6. factor -- (an independent variable in statistics) 7. gene, cistron, factor -- ((genetics) a segment of DNA that is involved in producing a polypeptide chain; it can include regions preceding and following the coding DNA as well as introns between the exons; it is considered a unit of heredity; "genes were formerly called factors") Overview of verb factor The verb factor has 3 senses (first 1 from tagged texts) 1. (2) factor, factor in, factor out -- (resolve into factors; "a quantum computer can factor the number 15") 2. factor -- (be a contributing factor; "make things factor into a company's profitability") 3. factor, factor in, factor out -- (consider as relevant when making a decision; "You must factor in the recent developments") --- WordNet end ---