ELIZA cgi-bash version rev. 1.91
- Medical English LInking keywords finder for the PubMed Zipped Archive (ELIZA) -

return kwic search for factors out of >500 occurrences
295043 occurrences (No.82 in the rank) during 5 years in the PubMed. [no cache] 500 found
32) In this review, we discuss the GIT factors and physicochemical and biological barriers in the GIT.
--- ABSTRACT ---
PMID:34710529 DOI:10.1016/j.addr.2021.114021
2021 Advanced drug delivery reviews
* Oral nanomedicine for modulating immunity, intestinal barrier functions, and gut microbiome.
- The gastrointestinal tract (GIT) affects not only local diseases in the GIT but also various systemic diseases. Factors that can affect the health and disease of both GIT and the human body include 1) the mucosal immune system composed of the gut-associated lymphoid tissues and the lamina propria, 2) the intestinal barrier composed of mucus and intestinal epithelium, and 3) the gut microbiota. Selective delivery of drugs, including antigens, immune-modulators, intestinal barrier enhancers, and gut-microbiome manipulators, has shown promising results for oral vaccines, immune tolerance, treatment of inflammatory bowel diseases, and other systemic diseases, including cancer. However, physicochemical and biological barriers of the GIT present significant challenges for successful translation. With the advances of novel nanomaterials, oral nanomedicine has emerged as an attractive option to not only overcome these barriers but also to selectively deliver drugs to the target sites in GIT. In this review, we discuss the GIT factors and physicochemical and biological barriers in the GIT. Furthermore, we present the recent progress of oral nanomedicine for oral vaccines, immune tolerance, and anti-inflammation therapies. We also discuss recent advances in oral nanomedicine designed to fortify the intestinal barrier functions and modulate the gut microbiota and microbial metabolites. Finally, we opine about the future directions of oral nano-immunotherapy.
--- ABSTRACT END ---
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[frequency of next (right) word to factors]
(1)60 and (12)8 related (23)3 influence (34)2 from
(2)55 *null* (13)8 to (24)3 is (35)2 have
(3)41 that (14)7 of (25)3 relating (36)2 impact
(4)31 for (15)6 (e.g., (26)3 which (37)2 involved
(5)29 associated (16)6 contributing (27)3 with (38)2 shaping
(6)24 influencing (17)5 on (28)2 (including (39)2 should
(7)20 were (18)4 can (29)2 (pre-COVID-19); (40)2 using
(8)17 such (19)4 like (30)2 affecting (41)2 varied
(9)15 in (20)4 the (31)2 and/or (42)2 was
(10)11 are (21)3 as (32)2 at
(11)9 including (22)3 included (33)2 by

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--- WordNet output for factors --- Overview of noun factor The noun factor has 7 senses (first 4 from tagged texts) 1. (31) factor -- (anything that contributes causally to a result; "a number of factors determined the outcome") 2. (8) component, constituent, element, factor, ingredient -- (an abstract part of something; "jealousy was a component of his character"; "two constituents of a musical composition are melody and harmony"; "the grammatical elements of a sentence"; "a key factor in her success"; "humor: an effective ingredient of a speech") 3. (4) divisor, factor -- (one of two or more integers that can be exactly divided into another integer; "what are the 4 factors of 6?") 4. (1) agent, factor, broker -- (a businessman who buys or sells for another in exchange for a commission) 5. factor -- (any of the numbers (or symbols) that form a product when multiplied together) 6. factor -- (an independent variable in statistics) 7. gene, cistron, factor -- ((genetics) a segment of DNA that is involved in producing a polypeptide chain; it can include regions preceding and following the coding DNA as well as introns between the exons; it is considered a unit of heredity; "genes were formerly called factors") Overview of verb factor The verb factor has 3 senses (first 1 from tagged texts) 1. (2) factor, factor in, factor out -- (resolve into factors; "a quantum computer can factor the number 15") 2. factor -- (be a contributing factor; "make things factor into a company's profitability") 3. factor, factor in, factor out -- (consider as relevant when making a decision; "You must factor in the recent developments") --- WordNet end ---