ELIZA

return kwic search for factors out of >500 occurrences
295043 occurrences (No.82 in the rank) during 5 years in the PubMed. [no cache] 500 found

412) Biomaterials capable of controlling the release of multiple growth factors (GFs) could potentially promote the integration of co-transplanted neural progenitor cells (NPCs) and stimulate the plasticity and regenerability of the lesioned spinal cord.

--- ABSTRACT ---

PMID:23956230 DOI:10.1002/term.1797

2015 Journal of tissue engineering and regenerative medicine

* The influence of sustained dual-factor presentation on the expansion and differentiation of neural progenitors in affinity-binding alginate scaffolds.

- Biomaterials capable of controlling the release of multiple growth factors (GFs) could potentially promote the integration of co-transplanted neural progenitor cells (NPCs) and stimulate the plasticity and regenerability of the lesioned spinal cord. As a first step towards the employment of such a vehicle for cell therapy, this study examined the capability of an alginate-sulphate/alginate scaffold, able to capture and rigorously control the release of GFs, to promote the expansion and lineage differentiation of NPCs in vitro. Epidermal growth factor (EGF) and fibroblast growth factor-2 (bFGF) were affinity-bound to alginate-sulphate (200 ng/scaffold) and the bioconjugates were mixed with partially calcium-crosslinked alginate. NPCs isolated from 18 day-old rat embryo brains and seeded into the scaffold during preparation were found to proliferate and differentiate within the vehicle. A continuous release of both bFGF and EGF was noted for a period of 21 days. The concentrations of released GFs were sufficient to promote extensive NPC proliferation at initial cultivation times; the number of neurospheres in the scaffold was twice the number found in the 2D cultures supplemented with 20 ng/ml each factor every 3 days. Between days 10-14, when the GF concentrations had substantially declined, extensive cell migration from the neurospheres as well as lineage differentiation were noted in the scaffold; immunocytochemical analyses confirmed the presence of neurons, astrocytes and oligodendrocytes.The scaffold has a potential to serve as cell delivery vehicle, with proven capability to promote cell retention and expansion, while enabling NPC lineage differentiation in situ.

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[frequency of next (right) word to factors]

(1)62 for	(12)10 related	(23)3 using	(34)2 during
(2)44 null	(13)8 on	(24)3 which	(35)2 from
(3)36 that	(14)7 have	(25)3 with	(36)2 including
(4)34 associated	(15)7 such	(26)2 (age,	(37)2 independently
(5)31 and	(16)6 may	(27)2 along	(38)2 involved
(6)29 in	(17)4 influence	(28)2 as	(39)2 jointly
(7)20 were	(18)4 significantly	(29)2 c-Jun	(40)2 other
(8)14 influencing	(19)4 to	(30)2 can	(41)2 produced
(9)13 are	(20)3 across	(31)2 contribute	(42)2 was
(10)13 of	(21)3 among	(32)2 contributing
(11)10 affecting	(22)3 like	(33)2 diagnostic

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--- WordNet output for factors --- Overview of noun factor The noun factor has 7 senses (first 4 from tagged texts) 1. (31) factor -- (anything that contributes causally to a result; "a number of factors determined the outcome") 2. (8) component, constituent, element, factor, ingredient -- (an abstract part of something; "jealousy was a component of his character"; "two constituents of a musical composition are melody and harmony"; "the grammatical elements of a sentence"; "a key factor in her success"; "humor: an effective ingredient of a speech") 3. (4) divisor, factor -- (one of two or more integers that can be exactly divided into another integer; "what are the 4 factors of 6?") 4. (1) agent, factor, broker -- (a businessman who buys or sells for another in exchange for a commission) 5. factor -- (any of the numbers (or symbols) that form a product when multiplied together) 6. factor -- (an independent variable in statistics) 7. gene, cistron, factor -- ((genetics) a segment of DNA that is involved in producing a polypeptide chain; it can include regions preceding and following the coding DNA as well as introns between the exons; it is considered a unit of heredity; "genes were formerly called factors") Overview of verb factor The verb factor has 3 senses (first 1 from tagged texts) 1. (2) factor, factor in, factor out -- (resolve into factors; "a quantum computer can factor the number 15") 2. factor -- (be a contributing factor; "make things factor into a company's profitability") 3. factor, factor in, factor out -- (consider as relevant when making a decision; "You must factor in the recent developments") --- WordNet end ---