ELIZA

return kwic search for first out of >500 occurrences
378430 occurrences (No.48 in the rank) during 5 years in the PubMed. [no cache] 500 found

146) Despite the lack of conclusive data demonstrating enhanced clinical outcomes, our study found arginine vasopressin is used widely in the care of infants and children with single ventricle physiology after the first stage and subsequent palliative surgeries.

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PMID:34381743 DOI:10.3389/fped.2021.669055

2021 Frontiers in pediatrics

* International Survey on the Use of Arginine Vasopressin in the Postoperative Management of Single Ventricle Patients.

- Management of patients with single ventricle physiology after surgical palliation is challenging. Arginine vasopressin has gained popularity in recent years as a non-catecholamine vasoactive medication due to its unique properties. However, data regarding its use in the pediatric population is limited. Therefore, we designed a survey to explore whether and how clinicians use this medication in intensive care units for the postoperative management of single ventricle patients. This international survey aimed to assess usage, practices, and concepts related to arginine vasopressin in pediatric intensive care units worldwide. Directors of pediatric intensive care units who are members of the following international professional societies: European Society of Pediatric Neonatal Intensive Care, Association for European Pediatric and Congenital Cardiology, and Pediatric Cardiac Intensive Care Society were invited to participate in this survey. Of the 62 intensive care unit directors who responded, nearly half use arginine vasopressin in the postoperative management of neonatal single ventricle patients, and 90% also use the drug in subsequent surgical palliation. The primary indications are vasoplegia, hemodynamic instability, and refractory shock, although it is still considered a second-line medication. Conceptual benefits include improved hemodynamics and end-organ perfusion and decreased incidence of low cardiac output syndrome. Those practitioners who do not use arginine vasopressin cite lack of availability, fear of potential adverse effects, unclear indication for use, and lack of evidence suggesting improved outcomes. Both users and non-users described increased myocardial afterload and extreme vasoconstriction as potential disadvantages of the medication. Despite the lack of conclusive data demonstrating enhanced clinical outcomes, our study found arginine vasopressin is used widely in the care of infants and children with single ventricle physiology after the first stage and subsequent palliative surgeries. While many intensive care units use this medication, few had protocols, offering an area for further growth and development.

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(1)23 time	(17)5 reported	(35)3 two	(52)2 pandemic
(2)21 to	(18)4 6	(36)3 used	(53)2 part
(3)13 treatment	(19)4 attendance,	(37)3 years	(54)2 place
(4)12 step	(20)4 few	(38)2 2	(55)2 post-operative
(5)11 and	(21)4 responders	(40)2 Aid	(56)2 psychosis
(6)11 study	(23)3 3	(41)2 a	(57)2 quarter
(7)11 time,	(25)3 attendance	(42)2 attempt	(58)2 responders,
(8)10 we	(26)3 author,	(43)2 author	(59)2 review
(9)8 aid	(27)3 evidence	(44)2 confirmed	(60)2 round
(10)7 Affiliated	(28)3 in	(45)2 define	(61)2 six
(11)6 line	(29)3 kinetics	(46)2 detected	(62)2 third,
(12)6 report	(30)3 of	(47)2 dose,	(63)2 three
(13)6 scoping	(31)3 phase	(48)2 edition	(64)2 treatment,
(14)6 stage	(32)3 set	(49)2 hour	(65)2 visit
(15)6 year	(33)3 stage,	(50)2 it	(66)2 wave
(16)5 identified	(34)3 systematic	(51)2 list

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--- WordNet output for first --- =>初めて, 最初の, 第一の, はじめに, 最初, 第1 Overview of noun first The noun first has 6 senses (first 4 from tagged texts) 1. (9) first, number one -- (the first or highest in an ordering or series; "He wanted to be the first") 2. (5) first, number one, number 1 -- (the first element in a countable series; "the first of the month") 3. (1) beginning, commencement, first, outset, get-go, start, kickoff, starting time, showtime, offset -- (the time at which something is supposed to begin; "they got an early start"; "she knew from the get-go that he was the man for her") 4. (1) first base, first -- (the fielding position of the player on a baseball team who is stationed at first of the bases in the infield (counting counterclockwise from home plate)) 5. first, first-class honours degree -- (an honours degree of the highest class) 6. first gear, first, low gear, low -- (the lowest forward gear ratio in the gear box of a motor vehicle; used to start a car moving) Overview of adj first The adj first has 6 senses (first 5 from tagged texts) 1. (232) first -- (preceding all others in time or space or degree; "the first house on the right"; "the first day of spring"; "his first political race"; "her first baby"; "the first time"; "the first meetings of the new party"; "the first phase of his training") 2. (61) first, 1st -- (indicating the beginning unit in a series) 3. (4) inaugural, initiative, initiatory, first, maiden -- (serving to set in motion; "the magazine's inaugural issue"; "the initiative phase in the negotiations"; "an initiatory step toward a treaty"; "his first (or maiden) speech in Congress"; "the liner's maiden voyage") 4. (4) beginning, first -- (serving to begin; "the beginning canto of the poem"; "the first verse") 5. (3) first, foremost, world-class -- (ranking above all others; "was first in her class"; "the foremost figure among marine artists"; "the top graduate") 6. first -- (highest in pitch or chief among parts or voices or instruments or orchestra sections; "first soprano"; "the first violin section"; "played first horn") Overview of adv first The adv first has 4 senses (first 4 from tagged texts) 1. (58) first, firstly, foremost, first of all, first off -- (before anything else; "first we must consider the garter snake") 2. (40) first, for the first time -- (the initial time; "when Felix first saw a garter snake") 3. (9) first -- (before another in time, space, or importance; "I was here first"; "let's do this job first") 4. (4) foremost, first -- (prominently forward; "he put his best foot foremost") --- WordNet end ---