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66) This study is one of the first to demonstrate the beneficial effect of Nd:YAG lasers on the regeneration of bone defects which were left empty or filled with collagen sponge, suggesting its great potential in postoperative treatment targeting local bone healing.
2015 Journal of tissue engineering and regenerative medicine
* High-intensity Nd:YAG laser accelerates bone regeneration in calvarial defect models.
- High-power pulsed lasers have been recently regarded to be anabolic to bone, but in vivo evidence is still lacking. This study aimed to investigate the capacity of bone repair using a high-power, Q-switched, pulsed, neodymium-doped yttrium aluminium garnet (Nd:YAG) laser, using bilateral calvarial defect models having non-critical sized, 5 mm (rat) or 8 mm (rabbit) diameter. One of the bilateral defects, which were all filled with collagen sponge or left empty, was irradiated with a Nd:YAG laser once every 2 days for 2 weeks at a constant total fluence rate (344 J/cm(2) ), output power (0.75 W), pulse repetition rate (15 pps) and wavelength (1064 nm) and examined for the laser effect. The same experimental scheme was designed using a rabbit calvarial defect model implanted with sponge, which was explored for the dose effect of output power at 0.75 and 3 W with the same quantities of the other parameters. New bone formation was evaluated by micro-computed tomography-based analysis and histological observation at 4 weeks after surgery. Laser irradiation significantly increased new bone formation by approximately 45%, not only in the sponge-filled defects of rats but also when the defects were left empty, compared to the non-irradiated group. Consistently, both doses of output power (0.75 and 3 W) enhanced new bone formation, but there was no significant difference between the two doses. This study is one of the first to demonstrate the beneficial effect of Nd:YAG lasers on the regeneration of bone defects which were left empty or filled with collagen sponge, suggesting its great potential in postoperative treatment targeting local bone healing.
=>初めて, 最初の, 第一の, はじめに, 最初, 第1
Overview of noun first
The noun first has 6 senses (first 4 from tagged texts)
1. (9) first, number one -- (the first or highest in an ordering or series; "He wanted to be the
first")
2. (5) first, number one, number 1 -- (the first element in a countable series; "the first of the
month")
3. (1) beginning, commencement, first, outset, get-go, start, kickoff, starting time, showtime,
offset -- (the time at which something is supposed to begin; "they got an early start"; "she knew
from the get-go that he was the man for her")
4. (1) first base, first -- (the fielding position of the player on a baseball team who is stationed
at first of the bases in the infield (counting counterclockwise from home plate))
5. first, first-class honours degree -- (an honours degree of the highest class)
6. first gear, first, low gear, low -- (the lowest forward gear ratio in the gear box of a motor
vehicle; used to start a car moving)
Overview of adj first
The adj first has 6 senses (first 5 from tagged texts)
1. (232) first -- (preceding all others in time or space or degree; "the first house on the right";
"the first day of spring"; "his first political race"; "her first baby"; "the first time"; "the
first meetings of the new party"; "the first phase of his training")
2. (61) first, 1st -- (indicating the beginning unit in a series)
3. (4) inaugural, initiative, initiatory, first, maiden -- (serving to set in motion; "the
magazine's inaugural issue"; "the initiative phase in the negotiations"; "an initiatory step toward
a treaty"; "his first (or maiden) speech in Congress"; "the liner's maiden voyage")
4. (4) beginning, first -- (serving to begin; "the beginning canto of the poem"; "the first verse")
5. (3) first, foremost, world-class -- (ranking above all others; "was first in her class"; "the
foremost figure among marine artists"; "the top graduate")
6. first -- (highest in pitch or chief among parts or voices or instruments or orchestra sections;
"first soprano"; "the first violin section"; "played first horn")
Overview of adv first
The adv first has 4 senses (first 4 from tagged texts)
1. (58) first, firstly, foremost, first of all, first off -- (before anything else; "first we must
consider the garter snake")
2. (40) first, for the first time -- (the initial time; "when Felix first saw a garter snake")
3. (9) first -- (before another in time, space, or importance; "I was here first"; "let's do this
job first")
4. (4) foremost, first -- (prominently forward; "he put his best foot foremost")
--- WordNet end ---