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- Medical English LInking keywords finder for the PubMed Zipped Archive (ELIZA) -

return kwic search for functional out of >500 occurrences
267449 occurrences (No.100 in the rank) during 5 years in the PubMed. [cache]
154) Studies of the pathogenesis of functional impairment from polypharmacy may improve management strategies in both sexes.
--- ABSTRACT ---
PMID:33780539 DOI:10.1093/gerona/glab088
2021 The journals of gerontology. Series A, Biological sciences and medical sciences
* Polypharmacy Results in Functional Impairment in Mice: Novel Insights Into Age and Sex Interactions.
- Males and females may respond differently to medications, yet knowledge about sexual dimorphisms in the effects of polypharmacy remains limited, particularly in aging. This study aimed to assess the effect of high Drug Burden Index (DBI) polypharmacy treatment compared to control on physical function and behavior in young and old, male and female mice. We studied whether age and sex play a role in physical function and behavior following polypharmacy treatment and whether they are paralleled by differences in serum drug levels. Young (2.5 months) and old (21.5 months), C57BL/6 mice were randomized to control or high DBI polypharmacy treatment (simvastatin, metoprolol, oxybutynin, oxycodone, and citalopram; n = 6-8/group) for 4-6 weeks. Compared to control, polypharmacy reduced physical function (grip strength, rotarod latency, gait speed, and total distance), middle zone distance (increased anxiety), and nesting score (reduced activities of daily living) in mice of both ages and sexes (p < .001). Old animals had a greater decline in nesting score (p < .05) and midzone distance (p < .001) than young animals. Grip strength declined more in males than females (p < .05). Drug levels at steady state were not significantly different between polypharmacy-treated animals of both ages and sexes. We observed polypharmacy-induced functional impairment in both age and sex groups, with age and sex interactions in the degree of impairment, which were not explained by serum drug levels. Studies of the pathogenesis of functional impairment from polypharmacy may improve management strategies in both sexes.
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(1)24 connectivity (20)4 brain (39)3 material (58)2 interactions
(2)14 magnetic (21)4 changes (40)3 materials (59)2 interpretation
(3)13 and (22)4 group (41)3 organization (60)2 neuroimaging
(4)13 recovery (23)4 implications (42)3 tasks (61)2 organ
(5)11 role (24)4 networks (43)3 units (62)2 outcome
(6)8 analyses (25)4 training+CPM (44)2 Threshold (63)2 outcome,
(7)8 assays (26)3 *null* (45)2 academics, (64)2 outcomes,
(8)8 groups (27)3 activation (46)2 alteration (65)2 phenotypes
(9)8 outcomes (28)3 activity (47)2 antibodies (66)2 plasticity
(10)8 roles (29)3 annotation (48)2 architecture (67)2 profile
(11)8 training (30)3 attributes (49)2 characterization (68)2 rating
(12)6 MRI (31)3 capacity (50)2 consequence (69)2 reconstruction
(13)6 analysis (32)3 cure (51)2 defects (70)2 redundancy
(14)6 properties (33)3 effector (52)2 differences (71)2 relationship
(15)6 studies (34)3 effects (53)2 diversification (72)2 relevance
(16)5 consequences (35)3 enrichment (54)2 enzymes (73)2 selectivity
(17)5 impairment (36)3 foods (55)2 evaluation
(18)5 network (37)3 impact (56)2 groups,
(19)5 theory (38)3 limitations (57)2 integrity

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--- WordNet output for functional --- =>機能の, 関数の, 機能する, 機能上の, 実用的な, 機能的な Overview of adj functional The adj functional has 6 senses (first 2 from tagged texts) 1. (3) functional -- (designed for or capable of a particular function or use; "a style of writing in which every word is functional"; "functional architecture") 2. (1) functional -- (involving or affecting function rather than physiology; "functional deafness") 3. functional -- (relating to or based on function especially as opposed to structure; "the problem now is not a constitutional one; it is a functional one"; "delegates elected on a functional rather than a geographical basis") 4. functional, usable, useable, operable, operational -- (fit or ready for use or service; "the toaster was still functional even after being dropped"; "the lawnmower is a bit rusty but still usable"; "an operational aircraft"; "the dishwasher is now in working order") 5. functional -- (designed for or adapted to a function or use; "functional education selects knowledge that is concrete and usable rather than abstract and theoretical"; "functional architecture") 6. running, operative, functional, working -- ((of e.g. a machine) performing or capable of performing; "in running (or working) order"; "a functional set of brakes") --- WordNet end ---