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return kwic search for functional out of >500 occurrences
267449 occurrences (No.100 in the rank) during 5 years in the PubMed. [cache]

17) This prospective observational cohort study aims to examine changes of specific resting-state functional connectivity networks across different time points (pre- and 3-5 months postoperatively) in delirious patients compared to no-POD patients.

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PMID:33846284 DOI:10.1038/s41398-021-01304-y

2021 Translational psychiatry

* Neurocognitive disorders in the elderly: altered functional resting-state hyperconnectivities in postoperative delirium patients.

- Postoperative delirium (POD) represents a confusional state during days/weeks after surgery and is particularly frequent in elderly patients. Hardly any fMRI studies were conducted to understand the underlying pathophysiology of POD patients. This prospective observational cohort study aims to examine changes of specific resting-state functional connectivity networks across different time points (pre- and 3-5 months postoperatively) in delirious patients compared to no-POD patients. Two-hundred eighty-three elderly surgical patients underwent preoperative resting-state fMRI (46 POD). One-hundred seventy-eight patients completed postoperative scans (19 POD). For functional connectivity analyses, three functional connectivity networks with seeds located in the orbitofrontal cortex (OFC), nucleus accumbens (NAcc), and hippocampus were investigated. The relationship of POD and connectivity changes between both time points (course connectivity) were examined (ANOVA). Preoperatively, delirious patients displayed hyperconnectivities across the examined functional connectivity networks. In POD patients, connectivities within NAcc and OFC networks demonstrated a decrease in course connectivity [max. F = 9.03, p = 0.003; F = 4.47, p = 0.036, resp.]. The preoperative hyperconnectivity in the three networks in the patients at risk for developing POD could possibly indicate existing compensation mechanisms for subtle brain dysfunction. The observed pathophysiology of network function in POD patients at least partially involves dopaminergic pathways.

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[frequency of next (right) word to functional]

(1)24 connectivity	(20)4 brain	(39)3 material	(58)2 interactions
(2)14 magnetic	(21)4 changes	(40)3 materials	(59)2 interpretation
(3)13 and	(22)4 group	(41)3 organization	(60)2 neuroimaging
(4)13 recovery	(23)4 implications	(42)3 tasks	(61)2 organ
(5)11 role	(24)4 networks	(43)3 units	(62)2 outcome
(6)8 analyses	(25)4 training+CPM	(44)2 Threshold	(63)2 outcome,
(7)8 assays	(26)3 null	(45)2 academics,	(64)2 outcomes,
(8)8 groups	(27)3 activation	(46)2 alteration	(65)2 phenotypes
(9)8 outcomes	(28)3 activity	(47)2 antibodies	(66)2 plasticity
(10)8 roles	(29)3 annotation	(48)2 architecture	(67)2 profile
(11)8 training	(30)3 attributes	(49)2 characterization	(68)2 rating
(12)6 MRI	(31)3 capacity	(50)2 consequence	(69)2 reconstruction
(13)6 analysis	(32)3 cure	(51)2 defects	(70)2 redundancy
(14)6 properties	(33)3 effector	(52)2 differences	(71)2 relationship
(15)6 studies	(34)3 effects	(53)2 diversification	(72)2 relevance
(16)5 consequences	(35)3 enrichment	(54)2 enzymes	(73)2 selectivity
(17)5 impairment	(36)3 foods	(55)2 evaluation
(18)5 network	(37)3 impact	(56)2 groups,
(19)5 theory	(38)3 limitations	(57)2 integrity

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--- WordNet output for functional --- =>機能の, 関数の, 機能する, 機能上の, 実用的な, 機能的な Overview of adj functional The adj functional has 6 senses (first 2 from tagged texts) 1. (3) functional -- (designed for or capable of a particular function or use; "a style of writing in which every word is functional"; "functional architecture") 2. (1) functional -- (involving or affecting function rather than physiology; "functional deafness") 3. functional -- (relating to or based on function especially as opposed to structure; "the problem now is not a constitutional one; it is a functional one"; "delegates elected on a functional rather than a geographical basis") 4. functional, usable, useable, operable, operational -- (fit or ready for use or service; "the toaster was still functional even after being dropped"; "the lawnmower is a bit rusty but still usable"; "an operational aircraft"; "the dishwasher is now in working order") 5. functional -- (designed for or adapted to a function or use; "functional education selects knowledge that is concrete and usable rather than abstract and theoretical"; "functional architecture") 6. running, operative, functional, working -- ((of e.g. a machine) performing or capable of performing; "in running (or working) order"; "a functional set of brakes") --- WordNet end ---