ELIZA cgi-bash version rev. 1.91
- Medical English LInking keywords finder for the PubMed Zipped Archive (ELIZA) -

return kwic search for functional out of >500 occurrences
267449 occurrences (No.100 in the rank) during 5 years in the PubMed. [cache]
210) The therapeutic goal for the functional cure of CHB is the generation of antibodies against HBsAg.
--- ABSTRACT ---
PMID:39958926 DOI:10.1016/j.livres.2020.09.004
2021 Liver research
* B cell dysfunction in chronic hepatitis B virus infection.
- Chronic hepatitis B (CHB) remains a global health problem. The persistence of hepatitis B surface antigen (HBsAg) in the blood for longer than 6 months after the initial infection is a sign of CHB. The therapeutic goal for the functional cure of CHB is the generation of antibodies against HBsAg. However, the adaptive immune response of patients with CHB cannot generate an efficient antiviral response. Many previous studies have evaluated T cell function and T cell therapy specifically designed to counter hepatitis B virus (HBV) infection. As one of the major components of adaptive immunity, B cells also display dysfunctions in anti-HBsAg antibody (HBsAb) production and antigen presentation. Patients with CHB have amplification of CD19+CD10-CD27-CD21- atypical memory B cell subsets and CD19+CD24hiCD38hi regulatory B cells. Currently, no reviews have summarized specific B cell responses during CHB infection. Thus, in this study, we summarized B cell dysfunction during CHB progression and the potential mechanisms behind these dysfunctions to further our understanding of the mechanisms of adaptive immune response of B cells in the process of CHB development and help provide new methods and ideas for the treatment of CHB.
--- ABSTRACT END ---
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[frequency of next (right) word to functional]
(1)24 connectivity (20)4 brain (39)3 material (58)2 interactions
(2)14 magnetic (21)4 changes (40)3 materials (59)2 interpretation
(3)13 and (22)4 group (41)3 organization (60)2 neuroimaging
(4)13 recovery (23)4 implications (42)3 tasks (61)2 organ
(5)11 role (24)4 networks (43)3 units (62)2 outcome
(6)8 analyses (25)4 training+CPM (44)2 Threshold (63)2 outcome,
(7)8 assays (26)3 *null* (45)2 academics, (64)2 outcomes,
(8)8 groups (27)3 activation (46)2 alteration (65)2 phenotypes
(9)8 outcomes (28)3 activity (47)2 antibodies (66)2 plasticity
(10)8 roles (29)3 annotation (48)2 architecture (67)2 profile
(11)8 training (30)3 attributes (49)2 characterization (68)2 rating
(12)6 MRI (31)3 capacity (50)2 consequence (69)2 reconstruction
(13)6 analysis (32)3 cure (51)2 defects (70)2 redundancy
(14)6 properties (33)3 effector (52)2 differences (71)2 relationship
(15)6 studies (34)3 effects (53)2 diversification (72)2 relevance
(16)5 consequences (35)3 enrichment (54)2 enzymes (73)2 selectivity
(17)5 impairment (36)3 foods (55)2 evaluation
(18)5 network (37)3 impact (56)2 groups,
(19)5 theory (38)3 limitations (57)2 integrity

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--- WordNet output for functional --- =>機能の, 関数の, 機能する, 機能上の, 実用的な, 機能的な Overview of adj functional The adj functional has 6 senses (first 2 from tagged texts) 1. (3) functional -- (designed for or capable of a particular function or use; "a style of writing in which every word is functional"; "functional architecture") 2. (1) functional -- (involving or affecting function rather than physiology; "functional deafness") 3. functional -- (relating to or based on function especially as opposed to structure; "the problem now is not a constitutional one; it is a functional one"; "delegates elected on a functional rather than a geographical basis") 4. functional, usable, useable, operable, operational -- (fit or ready for use or service; "the toaster was still functional even after being dropped"; "the lawnmower is a bit rusty but still usable"; "an operational aircraft"; "the dishwasher is now in working order") 5. functional -- (designed for or adapted to a function or use; "functional education selects knowledge that is concrete and usable rather than abstract and theoretical"; "functional architecture") 6. running, operative, functional, working -- ((of e.g. a machine) performing or capable of performing; "in running (or working) order"; "a functional set of brakes") --- WordNet end ---