ELIZA cgi-bash version rev. 1.91
- Medical English LInking keywords finder for the PubMed Zipped Archive (ELIZA) -

return kwic search for functional out of >500 occurrences
267449 occurrences (No.100 in the rank) during 5 years in the PubMed. [cache]
281) Regenerative therapies exemplify an emerging disruptive innovation aimed at achieving structural and functional organ restitution.
--- ABSTRACT ---
PMID:34768825 DOI:10.3390/ijms222111394
2021 International journal of molecular sciences
* Mass Customized Outlook for Regenerative Heart Failure Care.
- Heart failure pathobiology is permissive to reparative intent. Regenerative therapies exemplify an emerging disruptive innovation aimed at achieving structural and functional organ restitution. However, mixed outcomes, complexity in use, and unsustainable cost have curtailed broader adoption, mandating the development of novel cardio-regenerative approaches. Lineage guidance offers a standardized path to customize stem cell fitness for therapy. A case in point is the molecular induction of the cardiopoiesis program in adult stem cells to yield cardiopoietic cell derivatives designed for heart failure treatment. Tested in early and advanced clinical trials in patients with ischemic heart failure, clinical grade cardiopoietic cells were safe and revealed therapeutic improvement within a window of treatment intensity and pre-treatment disease severity. With the prospect of mass customization, cardiopoietic guidance has been streamlined from the demanding, recombinant protein cocktail-based to a protein-free, messenger RNA-based single gene protocol to engineer affordable cardiac repair competent cells. Clinical trial biobanked stem cells enabled a systems biology deconvolution of the cardiopoietic cell secretome linked to therapeutic benefit, exposing a paracrine mode of action. Collectively, this new knowledge informs next generation regenerative therapeutics manufactured as engineered cellular or secretome mimicking cell-free platforms. Launching biotherapeutics tailored for optimal outcome and offered at mass production cost would contribute to advancing equitable regenerative care that addresses population health needs.
--- ABSTRACT END ---
[
right
kwic]
[frequency of next (right) word to functional]
(1)24 connectivity (20)4 brain (39)3 material (58)2 interactions
(2)14 magnetic (21)4 changes (40)3 materials (59)2 interpretation
(3)13 and (22)4 group (41)3 organization (60)2 neuroimaging
(4)13 recovery (23)4 implications (42)3 tasks (61)2 organ
(5)11 role (24)4 networks (43)3 units (62)2 outcome
(6)8 analyses (25)4 training+CPM (44)2 Threshold (63)2 outcome,
(7)8 assays (26)3 *null* (45)2 academics, (64)2 outcomes,
(8)8 groups (27)3 activation (46)2 alteration (65)2 phenotypes
(9)8 outcomes (28)3 activity (47)2 antibodies (66)2 plasticity
(10)8 roles (29)3 annotation (48)2 architecture (67)2 profile
(11)8 training (30)3 attributes (49)2 characterization (68)2 rating
(12)6 MRI (31)3 capacity (50)2 consequence (69)2 reconstruction
(13)6 analysis (32)3 cure (51)2 defects (70)2 redundancy
(14)6 properties (33)3 effector (52)2 differences (71)2 relationship
(15)6 studies (34)3 effects (53)2 diversification (72)2 relevance
(16)5 consequences (35)3 enrichment (54)2 enzymes (73)2 selectivity
(17)5 impairment (36)3 foods (55)2 evaluation
(18)5 network (37)3 impact (56)2 groups,
(19)5 theory (38)3 limitations (57)2 integrity

add keyword

--- WordNet output for functional --- =>機能の, 関数の, 機能する, 機能上の, 実用的な, 機能的な Overview of adj functional The adj functional has 6 senses (first 2 from tagged texts) 1. (3) functional -- (designed for or capable of a particular function or use; "a style of writing in which every word is functional"; "functional architecture") 2. (1) functional -- (involving or affecting function rather than physiology; "functional deafness") 3. functional -- (relating to or based on function especially as opposed to structure; "the problem now is not a constitutional one; it is a functional one"; "delegates elected on a functional rather than a geographical basis") 4. functional, usable, useable, operable, operational -- (fit or ready for use or service; "the toaster was still functional even after being dropped"; "the lawnmower is a bit rusty but still usable"; "an operational aircraft"; "the dishwasher is now in working order") 5. functional -- (designed for or adapted to a function or use; "functional education selects knowledge that is concrete and usable rather than abstract and theoretical"; "functional architecture") 6. running, operative, functional, working -- ((of e.g. a machine) performing or capable of performing; "in running (or working) order"; "a functional set of brakes") --- WordNet end ---