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298283 occurrences (No.79 in the rank) during 5 years in the PubMed. [no cache] 500 found
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298283 occurrences (No.79 in the rank) during 5 years in the PubMed. [no cache] 500 found
| 165) Conclusions : Our results further support the linkage results for the chromosome 6q region and reveal a novel candidate gene for CL±P. |
| PMID:24066709 DOI:10.1597/13-023 |
| 2015 The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association |
| * Fine Mapping of 6q23.1 Identifies TULP4 as Contributing to Clefts. |
| - Objective : The aim of this work was to fine-map the region 6q23.1, which obtained suggestive linkage signal (logarithm of the odds [LOD] score = 2.22 under a recessive model) to cleft lip with or without cleft palate (CL±P) in our previous genome-wide linkage scan to identify possible genetic variants that may contribute to CL±P. Design : We used densely spaced markers spanning the entire 6q23.1 region to test for association with CL±P in a family cohort sample. Setting : Clinical information and DNA samples were obtained from families in the Philippines at their homes or primary health care clinics. Participants : The study sample consisted of 477 subjects (224 females and 253 males), segregating isolated CL±P, from 72 living in the same area in the Philippines. Main Outcome Measure : Overtransmission of alleles to persons born with CL±P. Results : We found statistical evidence of association between a marker of TULP4 (rs651333) with CL±P (P = .00007). Conclusions : Our results further support the linkage results for the chromosome 6q region and reveal a novel candidate gene for CL±P. |
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