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- Medical English LInking keywords finder for the PubMed Zipped Archive (ELIZA) -
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kwic search for gene out of >500 occurrences
403337 occurrences (No.43 in the rank) during 5 years in the PubMed. [no cache]
500 found
342) Using structured illumination microscopy together with advanced spinning disk confocal microscopy we show that these cells provide a powerful system for single gene analysis.
* Drosophila pupal macrophages--a versatile tool for combined ex vivo and in vivo imaging of actin dynamics at high resolution.
- Molecular understanding of actin dynamics requires a genetically traceable model system that allows live cell imaging together with high-resolution microscopy techniques. Here, we used Drosophila pupal macrophages that combine many advantages of cultured cells with a genetic in vivo model system. Using structured illumination microscopy together with advanced spinning disk confocal microscopy we show that these cells provide a powerful system for single gene analysis. It allows forward genetic screens to characterize the regulatory network controlling cell shape and directed cell migration in a physiological context. We knocked down components regulating lamellipodia formation, including WAVE, single subunits of Arp2/3 complex and CPA, one of the two capping protein subunits and demonstrate the advantages of this model system by imaging mutant macrophages ex vivo as well as in vivo upon laser-induced wounding.
=>遺伝子
Overview of noun gene
The noun gene has 1 sense (no senses from tagged texts)
1. gene, cistron, factor -- ((genetics) a segment of DNA that is involved in producing a polypeptide
chain; it can include regions preceding and following the coding DNA as well as introns between the
exons; it is considered a unit of heredity; "genes were formerly called factors")
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