344) Visual spatial memory was assessed using the Visual Spatial Learning Test (VSLT) in individuals with mild to moderate Huntington's disease (HD), pre-manifest gene carriers for HD, and demographically similar controls. |
PMID:24330469 DOI:10.1111/jnp.12036 |
2015 Journal of neuropsychology |
* The Visual Spatial Learning Test: differential impairment during the premanifest and manifest stages of Huntington's disease. |
- Visual spatial memory was assessed using the Visual Spatial Learning Test (VSLT) in individuals with mild to moderate Huntington's disease (HD), pre-manifest gene carriers for HD, and demographically similar controls. The VSLT has been demonstrated to be a valid, normed measure of non-verbal memory involving minimal motoric responses. The VSLT assesses immediate and delayed memory for designs, positions of the designs, and design/position associations. The HD group was significantly impaired (p < .05) relative to both the control and Pre-HD groups on immediate and delayed memory for the designs, positions, and design/position associations. Although there were no differences between the Pre-HD and control groups on immediate or delayed memory for designs or positions, the Pre-HD group was significantly impaired (p < .05) relative to the control group on immediate and delayed memory for design/position associations. The results offer novel insight into a relatively unexamined memory deficit that may occur in gene carriers for HD prior to phenoconversion. The data indicate that the VSLT may be a useful measure of visuospatial memory during the premanifest and manifest stages of HD. |
(1)75 expression | (15)5 of | (29)3 block | (43)2 mutation |
(2)34 order | (16)5 transfer | (30)3 can | (44)2 on |
(3)32 arrangement | (17)5 were | (31)3 contents | (45)2 overlap |
(4)31 and | (18)4 activation | (32)3 polymorphisms | (46)2 peptide |
(5)21 *null* | (19)4 delivery | (33)3 sequencing | (47)2 profiling |
(6)15 was | (20)4 encoding | (34)3 transcription | (48)2 regions |
(7)12 expression, | (21)4 expressions | (35)2 analysis | (49)2 sequence |
(8)9 arrangement, | (22)4 fragments | (36)2 carriers | (50)2 sequences, |
(9)7 composition | (23)4 is | (37)2 cluster | (51)2 spookier |
(10)7 organization | (24)4 silencing | (38)2 clusters | (52)2 synteny |
(11)7 sequences | (25)4 to | (39)2 content | (53)2 therapy, |
(12)5 flow | (26)4 which | (40)2 family | (54)2 used |
(13)5 for | (27)3 alterations | (41)2 from | (55)2 uses |
(14)5 in | (28)3 as | (42)2 has |
add keyword