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403337 occurrences (No.43 in the rank) during 5 years in the PubMed. [no cache] 500 found

346) Deeper analyses revealed 382 gene transcripts varied by age and 315 varied by sex in at least one tissue, with expression correlating with digitally imaged histologic tissue features.

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PMID:34732773 DOI:10.1038/s41598-021-00943-x

2021 Scientific reports

* Tissue, age, sex, and disease patterns of matrisome expression in GTEx transcriptome data.

- The extracellular matrix (ECM) has historically been explored through proteomic methods. Whether or not global transcriptomics can yield meaningful information on the human matrisome is unknown. Gene expression data from 17,382 samples across 52 tissues, were obtained from the Genotype-Tissue Expression (GTEx) project. Additional datasets were obtained from The Cancer Genome Atlas (TCGA) program and the Gene Expression Omnibus for comparisons. Gene expression levels generally matched proteome-derived matrisome expression patterns. Further, matrisome gene expression properly clustered tissue types, with some matrisome genes including SERPIN family members having tissue-restricted expression patterns. Deeper analyses revealed 382 gene transcripts varied by age and 315 varied by sex in at least one tissue, with expression correlating with digitally imaged histologic tissue features. A comparison of TCGA tumor, TCGA adjacent normal and GTEx normal tissues demonstrated robustness of the GTEx samples as a generalized matrix control, while also determining a common primary tumor matrisome. Additionally, GTEx tissues served as a useful non-diseased control in a separate study of idiopathic pulmonary fibrosis (IPF) matrix changes, while identifying 22 matrix genes upregulated in IPF. Altogether, these findings indicate that the transcriptome, in general, and GTEx in particular, has value in understanding the state of organ ECM.

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(1)132 expression	(14)5 drive	(27)3 duplications	(40)2 for
(2)14 null	(15)5 editing	(28)3 ontology	(41)2 from
(3)12 expression,	(16)5 mutations	(29)3 signature	(42)2 fusion,
(4)11 and	(17)5 of	(30)3 to	(43)2 have
(5)10 encoding	(18)5 regulation	(31)3 which	(44)2 is
(6)10 set	(19)4 networks	(32)2 analysis	(45)2 ontologies
(7)8 in	(20)4 regulatory	(33)2 are	(46)2 or
(8)8 that	(21)4 silencing	(34)2 assay,	(47)2 pathways
(9)7 1	(22)4 transcription	(35)2 called	(48)2 profile
(10)6 interaction	(23)4 transfer	(36)2 cluster	(49)2 promoter
(11)6 therapy	(24)3 1/itaconate	(37)2 delivery	(50)2 sequencing
(12)6 was	(25)3 co-expression	(38)2 detection	(51)2 sets
(13)5 Expression	(26)3 coexpression	(39)2 expressions	(52)2 transcripts

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--- WordNet output for gene --- =>遺伝子 Overview of noun gene The noun gene has 1 sense (no senses from tagged texts) 1. gene, cistron, factor -- ((genetics) a segment of DNA that is involved in producing a polypeptide chain; it can include regions preceding and following the coding DNA as well as introns between the exons; it is considered a unit of heredity; "genes were formerly called factors") --- WordNet end ---