359) They are characterized by the presence of reciprocal translocation between the CHOP (DDIT3) gene on chromosome 12 and the FUS gene on chromosome 16, t(12;16)(q13;p11.2) in >95% of cases, or less commonly, a translocation between the DDIT3 and EWSR1 genes, t(12;22)(q13;q12). |
PMID:23958553 DOI:10.1097/PAI.0b013e31829804f7 |
2015 Applied immunohistochemistry & molecular morphology : AIMM |
* Novel Clonal t(2;4) (q23;p14) Secondary Cytogenetic Abnormality in a Primary Myxoid Liposarcoma. |
- Myxoid liposarcomas are malignant lipomatous tumors with a predilection for young adults. They are characterized by the presence of reciprocal translocation between the CHOP (DDIT3) gene on chromosome 12 and the FUS gene on chromosome 16, t(12;16)(q13;p11.2) in >95% of cases, or less commonly, a translocation between the DDIT3 and EWSR1 genes, t(12;22)(q13;q12). Secondary aberrations involving trisomy 8 and chromosomes 1 and 16 have been reported. Herein, we report for the first time a novel secondary clonal translocation, t(2;4) (q23;p14) in addition to t(12;16)(q13; p11.2) in a 30-year-old woman with myxoid liposarcoma on the left posterior thigh region without any prior chemoradiation therapy. The significance of this translocation remains to be established. |
(1)75 expression | (15)5 of | (29)3 block | (43)2 mutation |
(2)34 order | (16)5 transfer | (30)3 can | (44)2 on |
(3)32 arrangement | (17)5 were | (31)3 contents | (45)2 overlap |
(4)31 and | (18)4 activation | (32)3 polymorphisms | (46)2 peptide |
(5)21 *null* | (19)4 delivery | (33)3 sequencing | (47)2 profiling |
(6)15 was | (20)4 encoding | (34)3 transcription | (48)2 regions |
(7)12 expression, | (21)4 expressions | (35)2 analysis | (49)2 sequence |
(8)9 arrangement, | (22)4 fragments | (36)2 carriers | (50)2 sequences, |
(9)7 composition | (23)4 is | (37)2 cluster | (51)2 spookier |
(10)7 organization | (24)4 silencing | (38)2 clusters | (52)2 synteny |
(11)7 sequences | (25)4 to | (39)2 content | (53)2 therapy, |
(12)5 flow | (26)4 which | (40)2 family | (54)2 used |
(13)5 for | (27)3 alterations | (41)2 from | (55)2 uses |
(14)5 in | (28)3 as | (42)2 has |
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