ELIZA

return kwic search for gene out of >500 occurrences
403337 occurrences (No.43 in the rank) during 5 years in the PubMed. [no cache] 500 found

6) Gene expression data indicate that EPCs, or their soluble products, modulate the expression of the β-cell surface molecule connexin 36 and affect glucose-stimulated insulin release in vitro.

--- ABSTRACT ---

PMID:24069942 DOI:10.3727/096368913X673423

2015 Cell transplantation

* Endothelial progenitor cells enhance islet engraftment, influence β-cell function, and modulate islet connexin 36 expression.

- The success of pancreatic islet transplantation is limited by delayed engraftment and suboptimal function in the longer term. Endothelial progenitor cells (EPCs) represent a potential cellular therapy that may improve the engraftment of transplanted pancreatic islets. In addition, EPCs may directly affect the function of pancreatic β-cells. The objective of this study was to examine the ability of EPCs to enhance pancreatic islet transplantation in a murine syngeneic marginal mass transplant model and to examine the mechanisms through which this occurs. We found that cotransplanted EPCs improved the cure rate and initial glycemic control of transplanted islets. Gene expression data indicate that EPCs, or their soluble products, modulate the expression of the β-cell surface molecule connexin 36 and affect glucose-stimulated insulin release in vitro. In conclusion, EPCs are a promising candidate for improving outcomes in islet transplantation, and their mechanisms of action warrant further study.

--- ABSTRACT END ---

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(1)75 expression	(15)5 of	(29)3 block	(43)2 mutation
(2)34 order	(16)5 transfer	(30)3 can	(44)2 on
(3)32 arrangement	(17)5 were	(31)3 contents	(45)2 overlap
(4)31 and	(18)4 activation	(32)3 polymorphisms	(46)2 peptide
(5)21 null	(19)4 delivery	(33)3 sequencing	(47)2 profiling
(6)15 was	(20)4 encoding	(34)3 transcription	(48)2 regions
(7)12 expression,	(21)4 expressions	(35)2 analysis	(49)2 sequence
(8)9 arrangement,	(22)4 fragments	(36)2 carriers	(50)2 sequences,
(9)7 composition	(23)4 is	(37)2 cluster	(51)2 spookier
(10)7 organization	(24)4 silencing	(38)2 clusters	(52)2 synteny
(11)7 sequences	(25)4 to	(39)2 content	(53)2 therapy,
(12)5 flow	(26)4 which	(40)2 family	(54)2 used
(13)5 for	(27)3 alterations	(41)2 from	(55)2 uses
(14)5 in	(28)3 as	(42)2 has

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--- WordNet output for gene --- =>遺伝子 Overview of noun gene The noun gene has 1 sense (no senses from tagged texts) 1. gene, cistron, factor -- ((genetics) a segment of DNA that is involved in producing a polypeptide chain; it can include regions preceding and following the coding DNA as well as introns between the exons; it is considered a unit of heredity; "genes were formerly called factors") --- WordNet end ---