ELIZA

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385944 occurrences (No.46 in the rank) during 5 years in the PubMed. [no cache] 500 found

199) Group I served as a control and is incubated with vehicle (toluene).

--- ABSTRACT ---

PMID:23572394 DOI:10.1177/0748233713475504

2015 Toxicology and industrial health

* Ameliorative effect of lycopene against 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced rat liver microsomal toxicity: an in vitro study.

- The objective of the current study was to investigate the potential oxidative damage of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in hepatic microsomal fractions in vitro and to further elucidate the potential modulatory effect of lycopene. Rat liver microsomes were divided into four groups. Group I served as a control and is incubated with vehicle (toluene). Groups II and IV were incubated with 20 µM lycopene for 1 h before further incubating; groups III and IV with 15 nM of TCDD for further 1 h. Hydrogen peroxide (H2O2) production, lipid peroxidation (LPO), protein carbonyl content and activities of uridine 5'-diphospho-glucuronyltransferase (UDPGT) and P450 were significantly increased. Moreover, the activity of antioxidant enzymes superoxide dismutase, glutathione peroxidase, catalse, glutathione-S-transferase and glutathione reductase as well as the microsomal thiol content were significantly decreased. Incubation with lycopene (group IV) maintained near normal activities of the enzymes, normalized thiol and carbonyl content and significantly reduced LPO and H2O2 production. In conclusion, the findings of the study indicate that TCDD induces a significant oxidative stress in liver microsomes as manifested by increased LPO, H2O2 production, protein carbonyl content and activities of UDPGT and P450 and decreased antioxidant enzymes activities and thiol content. By the reversal of biochemical and oxidative markers toward normalcy, the protective role of lycopene is illuminated in rat liver microsomal toxicity.

--- ABSTRACT END ---

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(1)49 null	(15)7 received	(29)3 II	(44)2 difference
(2)33 was	(16)5 at	(30)3 after	(45)2 displayed
(3)29 and	(17)5 for	(31)3 comprised	(46)2 dynamics-based
(4)25 of	(18)5 the	(32)3 in	(47)2 exhibited
(5)16 compared	(19)5 to	(33)3 when	(48)2 however,
(6)12 A	(20)4 (p	(34)2 (30	(49)2 improved
(7)12 were	(21)4 B	(35)2 (n	(50)2 included
(8)11 discussions	(22)4 C	(37)2 B,	(51)2 intervention
(9)10 than	(23)4 differences	(38)2 III	(52)2 interventions
(10)9 I	(24)4 or	(39)2 V	(53)2 interviews
(11)8 had	(25)3 1,	(40)2 a	(54)2 patients
(12)8 showed	(26)3 2	(41)2 as	(55)2 presented
(13)8 with	(27)3 4	(42)2 contains	(56)2 that
(14)7 1	(28)3 A,	(43)2 demonstrated

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--- WordNet output for group --- =>一団にする, 集める, 分派, 集団, グループ, 分類する, 演奏家グループ, 集まる, 分ける Overview of noun group The noun group has 3 senses (first 2 from tagged texts) 1. (1345) group, grouping -- (any number of entities (members) considered as a unit) 2. (1) group, radical, chemical group -- ((chemistry) two or more atoms bound together as a single unit and forming part of a molecule) 3. group, mathematical group -- (a set that is closed, associative, has an identity element and every element has an inverse) Overview of verb group The verb group has 2 senses (first 2 from tagged texts) 1. (4) group -- (arrange into a group or groups; "Can you group these shapes together?") 2. (1) group, aggroup -- (form a group or group together) --- WordNet end ---