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385944 occurrences (No.46 in the rank) during 5 years in the PubMed. [no cache] 500 found

26) Regeneration of axons and NMJs was demonstrated histologically in the nerve guidance group.

--- ABSTRACT ---

PMID:23401429 DOI:10.1002/term.1696

2015 Journal of tissue engineering and regenerative medicine

* Functional recovery of denervated muscle by neurotization using nerve guidance channels.

- Tissue-engineered muscle has been proposed as a means of repairing volumetric muscle defects to restore anatomical and functional recovery. We have previously demonstrated that denervated muscle, which is analogous to engineered muscle construct, can be reinnervated by direct transplantation of host nerve (neurotization) in a rat model. However, the use of this approach is not possible if the length of host nerve is inadequate and cannot be mobilized to the insertion site of the engineered muscle. In this study we investigated whether neurotization coupled with nerve guidance channels would increase the regeneration of neuromuscular junctions (NMJs) in completely denervated muscle and encourage neurofunctional recovery. Seventy-two Lewis rats were evaluated in three groups, a normal control group (n = 8), a denervated group (n = 32) and a neurotization coupled with nerve guidance group (n = 32). Neurofunctional behaviour and histological evaluations were performed at 4, 8, 12 and 20 weeks postoperatively. Extensor postural thrust (EPT) and compound muscle action potential (CMAP) amplitude were significantly improved in the nerve guidance group when compared with the denervated group, even though these values were different from those of the normal control group at 20 weeks postoperation. Regeneration of axons and NMJs was demonstrated histologically in the nerve guidance group. Neurotization coupled with nerve guidance channels leads to regeneration of axons and NMJs in completely denervated muscle. To our knowledge, this is the first report to show that nerve guidance can allow re-innervation in denervated muscle containing long-gap nerve injuries.

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(9)10 than	(23)4 differences	(38)2 III	(52)2 interventions
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--- WordNet output for group --- =>一団にする, 集める, 分派, 集団, グループ, 分類する, 演奏家グループ, 集まる, 分ける Overview of noun group The noun group has 3 senses (first 2 from tagged texts) 1. (1345) group, grouping -- (any number of entities (members) considered as a unit) 2. (1) group, radical, chemical group -- ((chemistry) two or more atoms bound together as a single unit and forming part of a molecule) 3. group, mathematical group -- (a set that is closed, associative, has an identity element and every element has an inverse) Overview of verb group The verb group has 2 senses (first 2 from tagged texts) 1. (4) group -- (arrange into a group or groups; "Can you group these shapes together?") 2. (1) group, aggroup -- (form a group or group together) --- WordNet end ---