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return kwic search for growth out of >500 occurrences
309169 occurrences (No.70 in the rank) during 5 years in the PubMed. [cache]

372) RYGB caused greater improvement in HbA1c, which was mediated by growth hormone receptor (GHR).

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PMID:34845204 DOI:10.1038/s41467-021-27289-2

2021 Nature communications

* High-throughput mediation analysis of human proteome and metabolome identifies mediators of post-bariatric surgical diabetes control.

- To improve the power of mediation in high-throughput studies, here we introduce High-throughput mediation analysis (Hitman), which accounts for direction of mediation and applies empirical Bayesian linear modeling. We apply Hitman in a retrospective, exploratory analysis of the SLIMM-T2D clinical trial in which participants with type 2 diabetes were randomized to Roux-en-Y gastric bypass (RYGB) or nonsurgical diabetes/weight management, and fasting plasma proteome and metabolome were assayed up to 3 years. RYGB caused greater improvement in HbA1c, which was mediated by growth hormone receptor (GHR). GHR's mediation is more significant than clinical mediators, including BMI. GHR decreases at 3 months postoperatively alongside increased insulin-like growth factor binding proteins IGFBP1/BP2; plasma GH increased at 1 year. Experimental validation indicates (1) hepatic GHR expression decreases in post-bariatric rats; (2) GHR knockdown in primary hepatocytes decreases gluconeogenic gene expression and glucose production. Thus, RYGB may induce resistance to diabetogenic effects of GH signaling.Trial Registration: Clinicaltrials.gov NCT01073020.

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(1)85 and	(12)4 performance	(25)2 as	(36)2 hormone
(2)71 factor	(13)4 phase	(26)2 compared	(37)2 lean
(3)51 of	(14)4 rate	(27)2 conditions	(38)2 on
(4)33 in	(15)4 restriction	(28)2 curve	(39)2 response
(5)26 null	(16)3 factor,	(29)2 curves	(40)2 stage
(6)12 inhibition	(19)3 failure	(30)2 defect	(41)2 the
(7)8 factors	(20)3 is	(31)2 during	(42)2 we
(8)7 plate	(21)3 rates,	(32)2 environmental	(43)2 were
(9)5 by	(22)3 was	(33)2 factor-beta
(10)4 factor-1	(23)3 will	(34)2 for
(11)4 mindset	(24)2 are	(35)2 functions

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--- WordNet output for growth --- =>茂み, 成長, 増加, 発展, 栽培, 腫よう, 成長物 Overview of noun growth The noun growth has 7 senses (first 5 from tagged texts) 1. (37) growth, growing, maturation, development, ontogeny, ontogenesis -- ((biology) the process of an individual organism growing organically; a purely biological unfolding of events involved in an organism changing gradually from a simple to a more complex level; "he proposed an indicator of osseous development in children") 2. (20) growth -- (a progression from simpler to more complex forms; "the growth of culture") 3. (3) increase, increment, growth -- (a process of becoming larger or longer or more numerous or more important; "the increase in unemployment"; "the growth of population") 4. (3) growth -- (vegetation that has grown; "a growth of trees"; "the only growth was some salt grass") 5. (1) emergence, outgrowth, growth -- (the gradual beginning or coming forth; "figurines presage the emergence of sculpture in Greece") 6. growth -- ((pathology) an abnormal proliferation of tissue (as in a tumor)) 7. growth -- (something grown or growing; "a growth of hair") --- WordNet end ---