ELIZA

return kwic search for health out of >500 occurrences
353463 occurrences (No.52 in the rank) during 5 years in the PubMed. [cache]

183) Di(2-ethylhexyl) phthalate (DEHP) and polychlorinated biphenyls (PCBs) are two widely distributed pollutants that are of great concern due to their adverse health effects.

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PMID:23804495 DOI:10.1002/tox.21885

2015 Environmental toxicology

* The combined effects of DEHP and PCBs on phospholipase in the livers of mice.

- Di(2-ethylhexyl) phthalate (DEHP) and polychlorinated biphenyls (PCBs) are two widely distributed pollutants that are of great concern due to their adverse health effects. However, few studies have investigated the combined effects of DEHP and PCBs. In this study, adult mice were continuously exposed to mixtures of DEHP (15 mg/kg bodyweight/day) and Aroclor 1254 (7.5 mg/kg bodyweight/day) for 12 days to investigate the combined effects of these compounds. The results showed that the ratio of the liver weight to the body weight was higher in the treated group than that in the control group. The effects of combined exposure on three important receptors, the proliferator-activated receptor (PPAR), estrogen receptor (ER), and aryl hydrocarbon receptor (AHR), were investigated. The mRNA level of PPARγ was significantly up-regulated after exposure. The expression level of ERα was decreased in the male treated group. In contrast, the expression levels of AHR and related genes (cyp1a1 and cyp1b1) were not markedly affected. The expression level of phospholipase A (PLA) was significantly down-regulated at both the mRNA and protein levels in male mice after combined treatment. In all, our study demonstrated the combined effects of DEHP and PCBs on the expression levels of key receptors in mice. The combined exposure led to a decrease in phospholipase in male mice.

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[frequency of next (right) word to health]

(1)73 care	(17)5 impact	(33)3 issues	(49)2 cost
(2)35 and	(18)5 impacts	(34)3 literacy	(50)2 data
(3)23 null	(19)5 insurance	(35)3 policy	(51)2 economic
(4)13 promotion	(20)5 problem	(36)3 risk	(52)2 examination
(5)12 Survey	(21)5 system	(37)3 risks	(53)2 factors
(6)12 professionals	(22)4 knowledge	(38)3 services,	(54)2 hazard
(7)8 education	(23)4 providers	(39)3 symptoms	(55)2 is
(8)8 effects	(24)4 surveillance	(40)3 was	(56)2 messages
(9)8 outcomes	(25)3 Insurance	(41)3 workers	(57)2 needs
(10)8 status	(26)3 Promotion	(42)2 Department	(58)2 plan
(11)7 problems	(27)3 as	(43)2 Organization's	(59)2 protection
(12)6 Organization	(28)3 authorities	(44)2 activities	(60)2 sector
(13)6 in	(29)3 centres	(45)2 benefits	(61)2 survey
(14)6 of	(30)3 conditions	(46)2 centers
(15)6 services	(31)3 hazards	(47)2 challenges
(16)5 behaviours	(32)3 interventions	(48)2 concern

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--- WordNet output for health --- =>健康状態, 健康, 調子 Overview of noun health The noun health has 2 senses (first 1 from tagged texts) 1. (21) health, wellness -- (a healthy state of wellbeing free from disease; "physicians should be held responsible for the health of their patients") 2. health -- (the general condition of body and mind; "his delicate health"; "in poor health") --- WordNet end ---