ELIZA

return kwic search for high out of >500 occurrences
636281 occurrences (No.11 in the rank) during 5 years in the PubMed. [cache]

137) Chitosan materials have shown promise as GBR barrier membranes, due to their biocompatibility and predictable biodegradability, but degradation rates may still be too high for clinical applications.

--- ABSTRACT ---

PMID:23166109 DOI:10.1002/term.1648

2015 Journal of tissue engineering and regenerative medicine

* Novel naturally crosslinked electrospun nanofibrous chitosan mats for guided bone regeneration membranes: material characterization and cytocompatibility.

- Guided bone regeneration (GBR) barrier membranes are used to prevent soft tissue infiltration into the graft space during dental procedures that involve bone grafting. Chitosan materials have shown promise as GBR barrier membranes, due to their biocompatibility and predictable biodegradability, but degradation rates may still be too high for clinical applications. In this study, chitosan GBR membranes were electrospun using chitosan (70% deacetylated, 312 kDa, 5.5 w/v%), with or without the addition of 5 or 10 mm genipin, a natural crosslinking agent, in order to extend the degradation to meet the clinical target time frame of 4-6 months. Membranes were evaluated for fibre diameter, tensile strength, biodegradation rate, bond structure and cytocompatibility. Genipin addition, at 5 or 10 mm, resulted in median fibre diameters 184, 144 and 154 nm for uncrosslinked, 5 mm and 10 mm crosslinked, respectively. Crosslinking, examined by Fourier transform infrared spectroscopy, showed a decrease in N-H stretch as genipin levels were increased. Genipin-crosslinked mats exhibited only 22% degradation based on mass loss, as compared to 34% for uncrosslinked mats at 16 weeks in vitro. The ultimate tensile strength of the mats was increased by 165% to 32 MPa with 10 mm crosslinking as compared to the uncrosslinked mats. Finally, genipin-crosslinked mats supported the proliferation of SAOS-2 cells in a 5 day growth study, similar to uncrosslinked mats. These results suggest that electrospun chitosan mats may benefit from genipin crosslinking and have the potential to meet clinical degradation time frames for GBR applications.

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[frequency of next (right) word to high]

(1)18 risk	(19)4 gamma	(37)2 AT	(55)2 importance
(2)14 and	(20)4 group	(38)2 N/L	(56)2 index
(3)12 prevalence	(21)4 patient	(39)2 PbB	(57)2 inter-specific
(4)10 levels	(22)4 rate	(40)2 accuracy	(58)2 internal
(5)9 level	(23)4 shear	(41)2 age	(59)2 job
(6)9 school	(24)3 blood	(42)2 alcohol	(60)2 mass
(7)8 null	(25)3 concentration	(43)2 areas	(61)2 population
(8)7 proportion	(26)3 density	(44)2 birth	(62)2 positive
(9)6 in	(27)3 dose	(45)2 caries	(63)2 production
(10)6 lipoprotein	(28)3 efficiency	(46)2 chemotherapy	(64)2 profile
(11)6 liquid	(29)3 frequency	(47)2 correlation	(65)2 relative
(12)6 mortality	(30)3 genetic	(48)2 dental	(66)2 reliability
(13)5 as	(31)3 groups	(49)2 diet	(67)2 resistance
(14)5 autism	(32)3 incidence	(50)2 exposure	(68)2 risks'
(15)5 degree	(33)3 patients	(51)2 expression	(69)2 specificity,
(16)4 concentrations	(34)3 rates	(52)2 frequencies	(70)2 technologies
(17)4 doses	(35)3 ulnar	(53)2 heart	(71)2 tumours
(18)4 for	(36)2 ASD	(54)2 hydrostatic	(72)2 variability

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--- WordNet output for high --- =>1.高いところにある, 高い, 高さが〜の, 高貴な, 高く, 高額の, 興奮状態の, 2.高い所, 高水準 Overview of noun high The noun high has 7 senses (first 1 from tagged texts) 1. (5) high -- (a lofty level or position or degree; "summer temperatures reached an all-time high") 2. high -- (an air mass of higher than normal pressure; "the east coast benefits from a Bermuda high") 3. high -- (a state of sustained elation; "I'm on a permanent high these days") 4. high -- (a state of altered consciousness induced by alcohol or narcotics; "they took drugs to get a high on") 5. high, heights -- (a high place; "they stood on high and observed the countryside"; "he doesn't like heights") 6. senior high school, senior high, high, highschool, high school -- (a public secondary school usually including grades 9 through 12; "he goes to the neighborhood highschool") 7. high gear, high -- (a forward gear with a gear ratio that gives the greatest vehicle velocity for a given engine speed) Overview of adj high The adj high has 7 senses (first 5 from tagged texts) 1. (134) high -- (greater than normal in degree or intensity or amount; "a high temperature"; "a high price"; "the high point of his career"; "high risks"; "has high hopes"; "the river is high"; "he has a high opinion of himself") 2. (51) high -- ((literal meaning) being at or having a relatively great or specific elevation or upward extension (sometimes used in combinations like `knee-high'); "a high mountain"; "high ceilings"; "high buildings"; "a high forehead"; "a high incline"; "a foot high") 3. (10) eminent, high -- (standing above others in quality or position; "people in high places"; "the high priest"; "eminent members of the community") 4. (7) high, high-pitched -- (used of sounds and voices; high in pitch or frequency) 5. (2) high, in high spirits -- (happy and excited and energetic) 6. gamey, gamy, high -- ((used of the smell of meat) smelling spoiled or tainted) 7. high, mellow -- (slightly and pleasantly intoxicated from alcohol or a drug (especially marijuana)) Overview of adv high The adv high has 4 senses (first 2 from tagged texts) 1. (9) high, high up -- (at a great altitude; "he climbed high on the ladder") 2. (2) high -- (in or to a high position, amount, or degree; "prices have gone up far too high") 3. high, richly, luxuriously -- (in a rich manner; "he lives high") 4. high -- (far up toward the source; "he lives high up the river") --- WordNet end ---