ELIZA

return kwic search for higher out of >500 occurrences
487192 occurrences (No.29 in the rank) during 5 years in the PubMed. [no cache] 500 found

345) The mean γ-glutamyltransferase, alanine, and aspartate aminotransaminase activity in groups of artemether-lumefantrine treated rats were significantly higher (p < 0.05) than that of the negative control group indicating that repeated administration of artemether-lumefantrine may be hepatotoxic.

--- ABSTRACT ---

PMID:24115283 DOI:10.1002/tox.21907

2015 Environmental toxicology

* Toxicity associated with repeated administration of artemether-lumefantrine in rats.

- Chemotherapy remains an important approach in the fight against malaria. Artemether-lumefantrine combination is widely in use due to its effectiveness against Plasmodium falciparum. Misuse in the form of multiple repeated doses of this anti-malaria drug is rampant in Nigeria. This study was designed to assess the hepatotoxic and clastogenic potential of extreme misuse of artemether-lumefantrine in rats. Graded doses of artemether-lumefantrine (1-5 mg/kg body weight) were administered by oral gavage for 6 weeks, twice daily, for 3 consecutive days per week. Artemether-lumefantrine, at all doses, did not have significant effects on the body and relative liver weight of treated group compared to the negative control group. The mean γ-glutamyltransferase, alanine, and aspartate aminotransaminase activity in groups of artemether-lumefantrine treated rats were significantly higher (p < 0.05) than that of the negative control group indicating that repeated administration of artemether-lumefantrine may be hepatotoxic. Findings from histological analyses of liver cross-section support the enzyme pattern of hepatoxicity. In addition, the drug, at all experimental doses, significantly induced (p < 0.05) formation of micronucleated polychromatic erythrocytes in the bone marrow cells of the treated rats compared with the negative control indicating clastogenic potential of the drug when misused.

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(1)69 in	(17)3 body	(33)2 by	(49)2 infant
(2)63 than	(18)3 fatalism	(34)2 concentrations	(50)2 initial
(3)21 levels	(19)3 likelihood	(35)2 coverage	(51)2 mean
(4)17 risk	(20)3 odds	(36)2 degree	(52)2 order
(5)10 level	(21)3 on	(37)2 different	(53)2 physiological
(6)9 among	(22)3 quality	(38)2 dose	(54)2 probability
(7)8 for	(23)2 (odds	(39)2 doses	(55)2 quantity
(8)6 rates	(24)2 null	(40)2 drug	(56)2 rate
(9)5 cell	(25)2 AT	(41)2 during	(57)2 relative
(10)5 potency	(26)2 MTBS	(42)2 education	(58)2 revision
(11)5 scores	(27)2 RDW	(43)2 education,	(59)2 sensitivity
(12)4 compared	(28)2 abstinence	(44)2 expectations	(60)2 stress
(13)4 number	(29)2 adjusted	(45)2 expression	(61)2 to
(14)4 prevalence	(30)2 amount	(46)2 frequency	(62)2 total
(15)3 (P	(31)2 birth	(47)2 incidence	(63)2 values
(16)3 amounts	(32)2 blood	(48)2 individual

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--- WordNet output for higher --- =>幹部, おえら方 Overview of adj higher The adj higher has 2 senses (first 2 from tagged texts) 1. (10) higher -- (advanced in complexity or elaboration; "higher finance"; "higher mathematics") 2. (1) higher -- (of education beyond the secondary level; "higher education"; "higher learning") Overview of adj high The adj high has 7 senses (first 5 from tagged texts) 1. (134) high -- (greater than normal in degree or intensity or amount; "a high temperature"; "a high price"; "the high point of his career"; "high risks"; "has high hopes"; "the river is high"; "he has a high opinion of himself") 2. (51) high -- ((literal meaning) being at or having a relatively great or specific elevation or upward extension (sometimes used in combinations like `knee-high'); "a high mountain"; "high ceilings"; "high buildings"; "a high forehead"; "a high incline"; "a foot high") 3. (10) eminent, high -- (standing above others in quality or position; "people in high places"; "the high priest"; "eminent members of the community") 4. (7) high, high-pitched -- (used of sounds and voices; high in pitch or frequency) 5. (2) high, in high spirits -- (happy and excited and energetic) 6. gamey, gamy, high -- ((used of the smell of meat) smelling spoiled or tainted) 7. high, mellow -- (slightly and pleasantly intoxicated from alcohol or a drug (especially marijuana)) --- WordNet end ---