ELIZA cgi-bash version rev. 1.91
- Medical English LInking keywords finder for the PubMed Zipped Archive (ELIZA) -
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kwic search for higher out of >500 occurrences
487192 occurrences (No.29 in the rank) during 5 years in the PubMed. [cache]
349) Immunisation experiments in mice demonstrated that the SARS-CoV-2 receptor binding domain (RBD) coupled to Dps (RBD-S-Dps) elicited a higher antibody titre and an enhanced neutralising antibody response compared to monomeric RBD.
* Single-dose immunisation with a multimerised SARS-CoV-2 receptor binding domain (RBD) induces an enhanced and protective response in mice.
- The COVID-19 pandemic, caused by the SARS-CoV-2 coronavirus, has triggered a worldwide health emergency. Here, we show that ferritin-like Dps from hyperthermophilic Sulfolobus islandicus, covalently coupled with SARS-CoV-2 antigens via the SpyCatcher system, forms stable multivalent dodecameric vaccine nanoparticles that remain intact even after lyophilisation. Immunisation experiments in mice demonstrated that the SARS-CoV-2 receptor binding domain (RBD) coupled to Dps (RBD-S-Dps) elicited a higher antibody titre and an enhanced neutralising antibody response compared to monomeric RBD. A single immunisation with RBD-S-Dps completely protected hACE2-expressing mice from serious illness and led to viral clearance from the lungs upon SARS-CoV-2 infection. Our data highlight that multimerised SARS-CoV-2 subunit vaccines are a highly efficacious modality, particularly when combined with an ultra-stable scaffold.
=>幹部, おえら方
Overview of adj higher
The adj higher has 2 senses (first 2 from tagged texts)
1. (10) higher -- (advanced in complexity or elaboration; "higher finance"; "higher mathematics")
2. (1) higher -- (of education beyond the secondary level; "higher education"; "higher learning")
Overview of adj high
The adj high has 7 senses (first 5 from tagged texts)
1. (134) high -- (greater than normal in degree or intensity or amount; "a high temperature"; "a
high price"; "the high point of his career"; "high risks"; "has high hopes"; "the river is high";
"he has a high opinion of himself")
2. (51) high -- ((literal meaning) being at or having a relatively great or specific elevation or
upward extension (sometimes used in combinations like `knee-high'); "a high mountain"; "high
ceilings"; "high buildings"; "a high forehead"; "a high incline"; "a foot high")
3. (10) eminent, high -- (standing above others in quality or position; "people in high places";
"the high priest"; "eminent members of the community")
4. (7) high, high-pitched -- (used of sounds and voices; high in pitch or frequency)
5. (2) high, in high spirits -- (happy and excited and energetic)
6. gamey, gamy, high -- ((used of the smell of meat) smelling spoiled or tainted)
7. high, mellow -- (slightly and pleasantly intoxicated from alcohol or a drug (especially
marijuana))
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