ELIZA

return kwic search for higher out of >500 occurrences
487192 occurrences (No.29 in the rank) during 5 years in the PubMed. [no cache] 500 found

354) Cultures using hWJSCs showed significantly higher GAGs accumulation and expression of cartilage-related genes (aggrecan, Sox9 and collagen type II) when compared to hBMSCs cultures.

--- ABSTRACT ---

PMID:24155167 DOI:10.1002/term.1812

2015 Journal of tissue engineering and regenerative medicine

* Conditioned medium as a strategy for human stem cells chondrogenic differentiation.

- Paracrine signalling from chondrocytes has been reported to increase the synthesis and expression of cartilage extracellular matrix (ECM) by stem cells. The use of conditioned medium obtained from chondrocytes for stimulating stem cells chondrogenic differentiation may be a very interesting alternative for moving into the clinical application of these cells, as chondrocytes could be partially replaced by stem cells for this type of application. In the present study we aimed to achieve chondrogenic differentiation of two different sources of stem cells using conditioned medium, without adding growth factors. We tested both human bone marrow-derived mesenchymal stem cells (hBSMCs) and human Wharton's jelly-derived stem cells (hWJSCs). Conditioned medium obtained from a culture of human articular chondrocytes was used to feed the cells during the experiment. Cultures were performed in previously produced three-dimensional (3D) scaffolds, composed of a blend of 50:50 chitosan:poly(butylene succinate). Both types of stem cells were able to undergo chondrogenic differentiation without the addition of growth factors. Cultures using hWJSCs showed significantly higher GAGs accumulation and expression of cartilage-related genes (aggrecan, Sox9 and collagen type II) when compared to hBMSCs cultures. Conditioned medium obtained from articular chondrocytes induced the chondrogenic differentiation of MSCs and ECM formation. Obtained results showed that this new strategy is very interesting and should be further explored for clinical applications.

--- ABSTRACT END ---

[
right
kwic]

[frequency of next (right) word to higher]

(1)69 in	(17)3 body	(33)2 by	(49)2 infant
(2)63 than	(18)3 fatalism	(34)2 concentrations	(50)2 initial
(3)21 levels	(19)3 likelihood	(35)2 coverage	(51)2 mean
(4)17 risk	(20)3 odds	(36)2 degree	(52)2 order
(5)10 level	(21)3 on	(37)2 different	(53)2 physiological
(6)9 among	(22)3 quality	(38)2 dose	(54)2 probability
(7)8 for	(23)2 (odds	(39)2 doses	(55)2 quantity
(8)6 rates	(24)2 null	(40)2 drug	(56)2 rate
(9)5 cell	(25)2 AT	(41)2 during	(57)2 relative
(10)5 potency	(26)2 MTBS	(42)2 education	(58)2 revision
(11)5 scores	(27)2 RDW	(43)2 education,	(59)2 sensitivity
(12)4 compared	(28)2 abstinence	(44)2 expectations	(60)2 stress
(13)4 number	(29)2 adjusted	(45)2 expression	(61)2 to
(14)4 prevalence	(30)2 amount	(46)2 frequency	(62)2 total
(15)3 (P	(31)2 birth	(47)2 incidence	(63)2 values
(16)3 amounts	(32)2 blood	(48)2 individual

add keyword

--- WordNet output for higher --- =>幹部, おえら方 Overview of adj higher The adj higher has 2 senses (first 2 from tagged texts) 1. (10) higher -- (advanced in complexity or elaboration; "higher finance"; "higher mathematics") 2. (1) higher -- (of education beyond the secondary level; "higher education"; "higher learning") Overview of adj high The adj high has 7 senses (first 5 from tagged texts) 1. (134) high -- (greater than normal in degree or intensity or amount; "a high temperature"; "a high price"; "the high point of his career"; "high risks"; "has high hopes"; "the river is high"; "he has a high opinion of himself") 2. (51) high -- ((literal meaning) being at or having a relatively great or specific elevation or upward extension (sometimes used in combinations like `knee-high'); "a high mountain"; "high ceilings"; "high buildings"; "a high forehead"; "a high incline"; "a foot high") 3. (10) eminent, high -- (standing above others in quality or position; "people in high places"; "the high priest"; "eminent members of the community") 4. (7) high, high-pitched -- (used of sounds and voices; high in pitch or frequency) 5. (2) high, in high spirits -- (happy and excited and energetic) 6. gamey, gamy, high -- ((used of the smell of meat) smelling spoiled or tainted) 7. high, mellow -- (slightly and pleasantly intoxicated from alcohol or a drug (especially marijuana)) --- WordNet end ---