ELIZA

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487192 occurrences (No.29 in the rank) during 5 years in the PubMed. [no cache] 500 found

94) Furthermore, compared to control flies, AD flies had significantly higher levels of the reactive oxygen species (ROS) hydrogen peroxide in their muscle-enriched thoraces.

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PMID:35366264 DOI:10.3390/pathophysiology28020020

2021 Pathophysiology : the official journal of the International Society for Pathophysiology

* The Angiotensin-Converting Enzyme Inhibitor Lisinopril Mitigates Memory and Motor Deficits in a Drosophila Model of Alzheimer's Disease.

- The use of angiotensin-converting enzyme inhibitors (ACEis) has been reported to reduce symptoms of cognitive decline in patients with Alzheimer’s disease (AD). Yet, the protective role of ACEis against AD symptoms is still controversial. Here, we aimed at determining whether oral treatment with the ACEi lisinopril has beneficial effects on cognitive and physical functions in a Drosophila melanogaster model of AD that overexpresses the human amyloid precursor protein and the human β-site APP-cleaving enzyme in neurons. We found a significant impairment in learning and memory as well as in climbing ability in young AD flies compared to control flies. After evaluation of the kynurenine pathway of tryptophan metabolism, we also found that AD flies displayed a >30-fold increase in the levels of the neurotoxic 3-hydroxykynurenine (3-HK) in their heads. Furthermore, compared to control flies, AD flies had significantly higher levels of the reactive oxygen species (ROS) hydrogen peroxide in their muscle-enriched thoraces. Lisinopril significantly improved deficits in learning and memory and climbing ability in AD flies. The positive impact of lisinopril on physical function might be, in part, explained by a significant reduction in ROS levels in the thoraces of the lisinopril-fed AD flies. However, lisinopril did not affect the levels of 3-HK. In conclusion, our findings provide novel and relevant insights into the therapeutic potential of ACEis in a preclinical AD model.

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(1)37 than	(14)5 mortality	(27)2 activation	(40)2 or
(2)33 in	(15)4 concentrations	(28)2 anti-E	(41)2 percentage
(3)28 levels	(16)4 proportion	(29)2 at	(42)2 performing
(4)27 risk	(17)4 rate	(30)2 auditory-perceptual	(43)2 potency
(5)11 rates	(18)4 regions	(31)2 cognitive	(44)2 risk,
(6)10 among	(19)3 consumption	(32)2 compared	(45)2 scores
(7)8 for	(20)3 frequency	(33)2 disease	(46)2 selectivity
(8)8 prevalence	(21)3 plasma	(34)2 doses	(47)2 social
(9)7 education	(22)3 quality	(35)2 endostatin	(48)2 stimulation
(10)7 level	(23)3 sensitivity	(36)2 extent	(49)2 to
(11)6 expression	(24)3 strength	(37)2 from	(50)2 tumor
(12)5 and	(25)2 F	(38)2 glutamate-cysteine	(51)2 weight
(13)5 incidence	(26)2 NAFLD	(39)2 odds

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--- WordNet output for higher --- =>幹部, おえら方 Overview of adj higher The adj higher has 2 senses (first 2 from tagged texts) 1. (10) higher -- (advanced in complexity or elaboration; "higher finance"; "higher mathematics") 2. (1) higher -- (of education beyond the secondary level; "higher education"; "higher learning") Overview of adj high The adj high has 7 senses (first 5 from tagged texts) 1. (134) high -- (greater than normal in degree or intensity or amount; "a high temperature"; "a high price"; "the high point of his career"; "high risks"; "has high hopes"; "the river is high"; "he has a high opinion of himself") 2. (51) high -- ((literal meaning) being at or having a relatively great or specific elevation or upward extension (sometimes used in combinations like `knee-high'); "a high mountain"; "high ceilings"; "high buildings"; "a high forehead"; "a high incline"; "a foot high") 3. (10) eminent, high -- (standing above others in quality or position; "people in high places"; "the high priest"; "eminent members of the community") 4. (7) high, high-pitched -- (used of sounds and voices; high in pitch or frequency) 5. (2) high, in high spirits -- (happy and excited and energetic) 6. gamey, gamy, high -- ((used of the smell of meat) smelling spoiled or tainted) 7. high, mellow -- (slightly and pleasantly intoxicated from alcohol or a drug (especially marijuana)) --- WordNet end ---