ELIZA cgi-bash version rev. 1.90
- Medical English LInking keywords finder for the PubMed Zipped Archive (ELIZA) -
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kwic search for identified out of >500 occurrences
324223 occurrences (No.64 in the rank) during 5 years in the PubMed. [cache]
327) In addition, we identified several miRNAs that are selectively upregulated in the postmitotic cINs, consistent with a role of miRNAs in the post-transcriptional control of the differentiation and apoptotic programs essential for cIN maturation.
* miRNAs are Essential for the Survival and Maturation of Cortical Interneurons.
- Complex and precisely orchestrated genetic programs contribute to the generation, migration, and maturation of cortical GABAergic interneurons (cIN). Yet, little is known about the signals that mediate the rapid alterations in gene expression that are required for cINs to transit through a series of developmental steps leading to their mature properties in the cortex. Here, we investigated the function of post-transcriptional regulation of gene expression by microRNAs on the development of cIN precursors. We find that conditional removal of the RNAseIII enzyme Dicer reduces the number of cINs in the adult mouse. Dicer is further necessary for the morphological and molecular maturation of cINs. Loss of mature miRNAs affects cINs development by impairing migration and differentiation of this cell type, while leaving proliferation of progenitors unperturbed. These developmental defects closely matched the abnormal expression of molecules involved in apoptosis and neuronal specification. In addition, we identified several miRNAs that are selectively upregulated in the postmitotic cINs, consistent with a role of miRNAs in the post-transcriptional control of the differentiation and apoptotic programs essential for cIN maturation. Thus, our results indicate that cIN progenitors require Dicer-dependent mechanisms to fine-tune the migration and maturation of cINs.
=>確認飛行物体;略:IFO
Overview of verb identify
The verb identify has 6 senses (first 6 from tagged texts)
1. (32) identify, place -- (recognize as being; establish the identity of someone or something; "She
identified the man on the 'wanted' poster")
2. (7) name, identify -- (give the name or identifying characteristics of; refer to by name or some
other identifying characteristic property; "Many senators were named in connection with the
scandal"; "The almanac identifies the auspicious months")
3. (6) identify -- (consider (oneself) as similar to somebody else; "He identified with the
refugees")
4. (4) identify -- (conceive of as united or associated; "Sex activity is closely identified with
the hypothalamus")
5. (2) identify, discover, key, key out, distinguish, describe, name -- (identify as in botany or
biology, for example)
6. (2) identify -- (consider to be equal or the same; "He identified his brother as one of the
fugitives")
Overview of adj identified
The adj identified has 1 sense (first 1 from tagged texts)
1. (1) identified -- (having the identity known or established; "the identified bodies were released
for burial")
--- WordNet end ---