ELIZA cgi-bash version rev. 1.91
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448856 occurrences (No.37 in the rank) during 5 years in the PubMed. [cache]
192) These results demonstrate the impact of cultural practices on population structure and genomic diversity in Pakistanis, and have important implications for medical genetic studies.
* Fine-scale population structure and demographic history of British Pakistanis.
- Previous genetic and public health research in the Pakistani population has focused on the role of consanguinity in increasing recessive disease risk, but little is known about its recent population history or the effects of endogamy. Here, we investigate fine-scale population structure, history and consanguinity patterns using genotype chip data from 2,200 British Pakistanis. We reveal strong recent population structure driven by the biraderi social stratification system. We find that all subgroups have had low recent effective population sizes (Ne), with some showing a decrease 15‒20 generations ago that has resulted in extensive identity-by-descent sharing and homozygosity, increasing the risk of recessive disorders. Our results from two orthogonal methods (one using machine learning and the other coalescent-based) suggest that the detailed reporting of parental relatedness for mothers in the cohort under-represents the true levels of consanguinity. These results demonstrate the impact of cultural practices on population structure and genomic diversity in Pakistanis, and have important implications for medical genetic studies.
=>重要な, 有力な, 重大な, 大切な
Overview of adj important
The adj important has 5 senses (first 4 from tagged texts)
1. (146) important, of import -- (of great significance or value; "important people"; "the important
questions of the day")
2. (4) significant, important -- (important in effect or meaning; "a significant change in tax
laws"; "a significant change in the Constitution"; "a significant contribution"; "significant
details"; "statistically significant")
3. (2) crucial, important -- (of extreme importance; vital to the resolution of a crisis; "a crucial
moment in his career"; "a crucial election"; "a crucial issue for women")
4. (1) authoritative, important -- (having authority or ascendancy or influence; "an important
official"; "the captain's authoritative manner")
5. important -- (having or suggesting a consciousness of high position; "recited the decree with an
important air"; "took long important strides in the direction of his office")
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