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return kwic search for important out of >500 occurrences
448856 occurrences (No.37 in the rank) during 5 years in the PubMed. [no cache] 500 found

292) Histatins are a family of endogenous antimicrobial peptides that have numerous important effects in multiple biological systems, including antifungal, antibacterial, cancer pathogenesis, immunomodulation, and wound healing.

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PMID:34233061 DOI:10.1111/febs.16108

2021 The FEBS journal

* Histatin-1 is an endogenous ligand of the sigma-2 receptor.

- The Sigma-2 receptor (S2R) (a.k.a TMEM97) is an important endoplasmic reticular protein involved in cancer, cholesterol processing, cell migration, and neurodegenerative diseases, including Niemann-Pick Type C. While several S2R pharmacologic agents have been discovered, its recent (2017) cloning has limited biological investigation, and no endogenous ligands of the S2R are known. Histatins are a family of endogenous antimicrobial peptides that have numerous important effects in multiple biological systems, including antifungal, antibacterial, cancer pathogenesis, immunomodulation, and wound healing. Histatin-1 (Hst1) has important roles in epithelial wound healing and cell migration, and is the primary wound healing agent in saliva. Little is understood about the downstream machinery that underpins the effects of histatins, and no mammalian receptor is known to date. In this study, we show, using biophysical methods and functional assays, that Hst1 is an endogenous ligand for S2R and that S2R is a mammalian receptor for Hst1.

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(1)46 for	(17)3 clinical	(33)2 benefits	(49)2 it
(2)46 role	(18)3 component	(34)2 biomarkers	(50)2 mechanistic
(3)45 to	(19)3 concern	(35)2 cause	(51)2 mediator
(4)15 null	(20)3 consideration	(36)2 cellular	(52)2 mediators
(5)13 roles	(21)3 contribution	(37)2 considerations	(53)2 methodological
(6)8 and	(22)3 contributor	(38)2 contributions	(54)2 of
(7)8 factors	(23)3 factor	(39)2 cytochrome	(55)2 part
(8)8 in	(24)3 information	(40)2 determinants	(56)2 place
(9)7 implications	(25)3 knowledge	(41)2 driver	(57)2 players
(10)5 components	(26)3 mechanisms	(42)2 effects	(58)2 public
(11)5 determinant	(27)3 new	(43)2 feature	(59)2 resource
(12)4 as	(28)3 questions	(44)2 immune	(60)2 risk
(13)4 biological	(29)3 step	(45)2 indicator	(61)2 source
(14)4 but	(30)3 strategy	(46)2 insight	(62)2 steps
(15)4 insights	(31)3 tool	(47)2 is	(63)2 target
(16)4 that	(32)2 aspects	(48)2 issue	(64)2 tools

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--- WordNet output for important --- =>重要な, 有力な, 重大な, 大切な Overview of adj important The adj important has 5 senses (first 4 from tagged texts) 1. (146) important, of import -- (of great significance or value; "important people"; "the important questions of the day") 2. (4) significant, important -- (important in effect or meaning; "a significant change in tax laws"; "a significant change in the Constitution"; "a significant contribution"; "significant details"; "statistically significant") 3. (2) crucial, important -- (of extreme importance; vital to the resolution of a crisis; "a crucial moment in his career"; "a crucial election"; "a crucial issue for women") 4. (1) authoritative, important -- (having authority or ascendancy or influence; "an important official"; "the captain's authoritative manner") 5. important -- (having or suggesting a consciousness of high position; "recited the decree with an important air"; "took long important strides in the direction of his office") --- WordNet end ---