* Inflammaging and proteases in abdominal aortic aneurysm.
- Abdominal aortic aneurysm (AAA) is an age-related disease resulting in aortic wall weakening and dilatation which may progress to the fatal point of abrupt aortic wall rupture. Chronic inflammation is a driving force in the pathogenesis of AAA and extracellular matrix (ECM) proteases are considered central to aortic wall degradation. Considerable effort is dedicated to identifying the proteases responsible as well as the mechanism by which these proteases contribute to disease progression. As such, they are considered important molecular targets for pharmacological intervention. Along with smoking, male gender and family history, aging is a major risk factor for AAA. Examination of age-related changes of the immune system reveals an interwoven relationship between the processes of aging and chronic inflammation, collectively predisposing to AAA development. The present review explores current evidence as to the role of specific ECM proteases in AAA pathogenesis. The contribution of the aging process to disease pathogenesis is also explored to provide the relevant context and highlight key molecular pathways that should be considered while attempting to develop effective treatment approaches.
=>重要な, 有力な, 重大な, 大切な
Overview of adj important
The adj important has 5 senses (first 4 from tagged texts)
1. (146) important, of import -- (of great significance or value; "important people"; "the important
questions of the day")
2. (4) significant, important -- (important in effect or meaning; "a significant change in tax
laws"; "a significant change in the Constitution"; "a significant contribution"; "significant
details"; "statistically significant")
3. (2) crucial, important -- (of extreme importance; vital to the resolution of a crisis; "a crucial
moment in his career"; "a crucial election"; "a crucial issue for women")
4. (1) authoritative, important -- (having authority or ascendancy or influence; "an important
official"; "the captain's authoritative manner")
5. important -- (having or suggesting a consciousness of high position; "recited the decree with an
important air"; "took long important strides in the direction of his office")
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