ELIZA cgi-bash version rev. 1.90
- Medical English LInking keywords finder for the PubMed Zipped Archive (ELIZA) -

return kwic search for increase out of >500 occurrences
611425 occurrences (No.13 in the rank) during 5 years in the PubMed. [cache]
402) Microbead formulations were optimized to increase drug loading, avoid precipitation and to achieve good in vitro dissolution performance.
--- ABSTRACT ---
PMID:24283499 DOI:10.3109/10837450.2013.860546
2015 Pharmaceutical development and technology
* Microbeads: a novel multiparticulate drug delivery technology for increasing the solubility and dissolution of celecoxib.
- The purpose of this study was to develop a novel multipaticulate drug delivery technology suitable for the delivery of pre-solubilized celecoxib to the gastrointestinal tract and more specifically to the colon. The solubility of celecoxib in a range of oils, surfactants and co-solvents was evaluated. Celecoxib was solubilized in mixtures of these vehicles to produce liquid formulations. The in vitro dissolution of these liquid formulations was assessed and the data obtained was used to design microbead formulations containing celecoxib dissolved within an emulsion/micellar solution core. Microbead formulations were optimized to increase drug loading, avoid precipitation and to achieve good in vitro dissolution performance. An optimized formulation with a celecoxib loading of 6% w/w was produced and yielded an in vitro dissolution result of 80% over 6 h. The structure of these microbead formulations was characterized using light microscopy to reveal a correlation between droplet size and dissolution performance.
--- ABSTRACT END ---
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(1)259 in (7)6 during (13)3 drug (19)2 ROM
(2)55 the (8)5 was (14)3 from (20)2 between
(3)36 of (9)5 with (15)3 or (21)2 chlamydia
(4)10 *null* (10)4 life (16)3 susceptibility (22)2 could
(5)7 physical (11)3 at (17)3 their (23)2 observed
(6)6 and (12)3 awareness (18)2 (P (24)2 our

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--- WordNet output for increase --- =>大きくなる, を増す, 増大させる, 強まる, 増加, 増える, 増やす Overview of noun increase The noun increase has 5 senses (first 5 from tagged texts) 1. (49) addition, increase, gain -- (a quantity that is added; "there was an addition to property taxes this year"; "they recorded the cattle's gain in weight over a period of weeks") 2. (21) increase -- (a change resulting in an increase; "the increase is scheduled for next month") 3. (7) increase, increment, growth -- (a process of becoming larger or longer or more numerous or more important; "the increase in unemployment"; "the growth of population") 4. (3) increase, increment -- (the amount by which something increases; "they proposed an increase of 15 percent in the fare") 5. (3) increase, step-up -- (the act of increasing something; "he gave me an increase in salary") Overview of verb increase The verb increase has 2 senses (first 2 from tagged texts) 1. (86) increase -- (become bigger or greater in amount; "The amount of work increased") 2. (61) increase -- (make bigger or more; "The boss finally increased her salary"; "The university increased the number of students it admitted") --- WordNet end ---