ELIZA

return kwic search for increased out of >500 occurrences
611425 occurrences (No.13 in the rank) during 5 years in the PubMed. [no cache] 500 found

140) The mean crypt length increased by 1% (P=0.92) in the calcium group, and decreased by 2% (P=0.69) and 4% (P=0.40) in the vitamin D and calcium plus vitamin D groups, respectively, relative to the placebo group.

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PMID:24115184 DOI:10.1002/mc.22090

2015 Molecular carcinogenesis

* Effects of calcium and vitamin D supplementation on crypt morphology in normal colon mucosa: A randomized clinical trial.

- Calcium and vitamin D modify the molecular phenotypic profiles of colon crypts in the normal colorectal mucosa of colorectal adenoma patients, but their effects on crypt morphology (length, perimeter, and area) are unknown. We analyzed data from a previously conducted pilot, randomized, double-blind, placebo-controlled 2 × 2 factorial chemoprevention clinical trial of supplemental calcium 2000 mg/d and vitamin D3 800 IU/d, alone and in combination, versus placebo over 6 mo. Colorectal crypt length, perimeter, and area in the normal-appearing rectal mucosa were quantified by image analysis. The mean crypt length increased by 1% (P=0.92) in the calcium group, and decreased by 2% (P=0.69) and 4% (P=0.40) in the vitamin D and calcium plus vitamin D groups, respectively, relative to the placebo group. The mean crypt perimeter decreased by 2% (P=0.70) and 4% (P=0.40) in the vitamin D and calcium plus vitamin D groups, respectively, relative to the placebo group, but did not change appreciably in the calcium group. The mean crypt area decreased by 2% (P=0.74), 5% (P=0.41) and 7% (P=0.30) in the calcium, vitamin D and calcium plus vitamin D groups, respectively, relative to the placebo group. Calcium and/or vitamin D3 supplementation do not appear to appreciably change crypt morphology in the normal colorectal mucosa of sporadic adenoma patients. These results, taken together with previous findings, support the use of molecular phenotypic over morphologic pre-neoplastic biomarkers of risk for colorectal neoplasms.

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(1)36 the	(14)5 to	(27)2 RDW	(40)2 likelihood
(2)34 in	(15)4 after	(28)2 awareness	(41)2 maternal
(3)27 risk	(16)4 as	(29)2 bone	(42)2 morbidity
(4)21 null	(17)3 activity	(30)2 but	(43)2 number
(5)20 with	(18)3 among	(31)2 compared	(44)2 over
(6)16 by	(19)3 at	(32)2 concentrations	(45)2 pre-stimulus
(7)15 significantly	(20)3 cell	(33)2 drug	(46)2 production
(8)6 and	(21)3 level	(34)2 during	(47)2 rapidly
(9)6 expression	(22)3 levels	(35)2 fax	(48)2 use
(10)6 from	(23)3 physical	(36)2 functional	(49)2 vascular
(11)5 activation	(24)3 sensitivity	(37)2 hepatic
(12)5 odds	(25)2 MI	(38)2 if
(13)5 serum	(26)2 Math1	(39)2 interest

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--- WordNet output for increased --- =>力の増加 Overview of verb increase The verb increase has 2 senses (first 2 from tagged texts) 1. (86) increase -- (become bigger or greater in amount; "The amount of work increased") 2. (61) increase -- (make bigger or more; "The boss finally increased her salary"; "The university increased the number of students it admitted") Overview of adj increased The adj increased has 1 sense (first 1 from tagged texts) 1. (30) increased -- (made greater in size or amount or degree) --- WordNet end ---