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611425 occurrences (No.13 in the rank) during 5 years in the PubMed. [no cache] 500 found
16) We found that MC-LR markedly increased the level of Tau phosphorylation with the dissociation of phosphorylated Tau from the cytoskeleton.
--- ABSTRACT ---
PMID:23929704 DOI:10.1002/tox.21898
2015 Environmental toxicology
* Alterations of tau and VASP during microcystin-LR-induced cytoskeletal reorganization in a human liver cell line.
- Previously, we have reported alterations to HSP27 during Microcystin-LR (MC-LR)-induced cytoskeletal reorganization in the human liver cell line HL7702. To further elucidate the detailed mechanism of MC-LR-induced cytoskeletal assembly, we focused on two cytoskeletal-related proteins, Tau and VASP. These two proteins phosphorylated status influences their ability to bind and stabilize cytoskeleton. We found that MC-LR markedly increased the level of Tau phosphorylation with the dissociation of phosphorylated Tau from the cytoskeleton. Furthermore, the phosphorylation of Tau induced by MC-LR was suppressed by an activator of PP2A and by an inhibitor of p38 MAPK. VASP was also hyperphosphorylated upon MC-LR exposure; however, its phosphorylation appeared to regulate its cellular localization rather than cytoskeletal dynamics, and its phosphorylation was unaffected by the PP2A activator. These data suggest that phosphorylated Tau is regulated by p38 MAPK, possibly as a consequence of PP2A inhibition. Tau hyperphosphorylation is likely an important factor leading to the cytoskeletal destabilization triggered by MC-LR and the role of VASP alteration upon MC-LR exposure needs to be studied further. To our knowledge, the finding that Tau is implicated in cytoskeletal destabilization in MC-LR-treated hepatocytes and MC-LR-induced VASP's alteration has not been reported previously.
--- ABSTRACT END ---
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[frequency of next (right) word to increased]
(1)36 the (14)5 to (27)2 RDW (40)2 likelihood
(2)34 in (15)4 after (28)2 awareness (41)2 maternal
(3)27 risk (16)4 as (29)2 bone (42)2 morbidity
(4)21 *null* (17)3 activity (30)2 but (43)2 number
(5)20 with (18)3 among (31)2 compared (44)2 over
(6)16 by (19)3 at (32)2 concentrations (45)2 pre-stimulus
(7)15 significantly (20)3 cell (33)2 drug (46)2 production
(8)6 and (21)3 level (34)2 during (47)2 rapidly
(9)6 expression (22)3 levels (35)2 fax (48)2 use
(10)6 from (23)3 physical (36)2 functional (49)2 vascular
(11)5 activation (24)3 sensitivity (37)2 hepatic
(12)5 odds (25)2 MI (38)2 if
(13)5 serum (26)2 Math1 (39)2 interest

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--- WordNet output for increased --- =>力の増加 Overview of verb increase The verb increase has 2 senses (first 2 from tagged texts) 1. (86) increase -- (become bigger or greater in amount; "The amount of work increased") 2. (61) increase -- (make bigger or more; "The boss finally increased her salary"; "The university increased the number of students it admitted") Overview of adj increased The adj increased has 1 sense (first 1 from tagged texts) 1. (30) increased -- (made greater in size or amount or degree) --- WordNet end ---